| Title: | Inducible and targeted deletion of the ERK5 MAP kinase in adult neurogenic regions impairs adult neurogenesis in the olfactory bulb and several forms of olfactory behavior |
| Author(s): | Pan YW; Kuo CT; Storm DR; Xia Z; |
| Address: | "Graduate Program in Molecular and Cellular Biology, University of Washington, Seattle, Washington, United States of America" |
| DOI: | 10.1371/journal.pone.0049622 |
| ISSN/ISBN: | 1932-6203 (Electronic) 1932-6203 (Linking) |
| Abstract: | "Although adult-born neurons in the subventricular zone (SVZ) and olfactory bulb (OB) have been extensively characterized at the cellular level, their functional impact on olfactory behavior is still highly controversial with many conflicting results reported in the literature. Furthermore, signaling mechanisms regulating adult SVZ/OB neurogenesis are not well defined. Here we report that inducible and targeted deletion of erk5, a MAP kinase selectively expressed in the adult neurogenic regions of the adult brain, impairs adult neurogenesis in the SVZ and OB of transgenic mice. Although erk5 deletion had no effect on olfactory discrimination among discrete odorants in the habituation/dishabituation assay, it reduced short-term olfactory memory as well as detection sensitivity to odorants and pheromones including those evoking aggression and fear. Furthermore, these mice show impaired acquisition of odor-cued associative olfactory learning, a novel phenotype that had not been previously linked to adult neurogenesis. These data suggest that ERK5 MAP kinase is a critical kinase signaling pathway regulating adult neurogenesis in the SVZ/OB, and provide strong evidence supporting a functional role for adult neurogenesis in several distinct forms of olfactory behavior" |
| Keywords: | "Animals Brain/physiology Bromodeoxyuridine/pharmacology Gene Deletion Male Mice Mice, Transgenic Microscopy, Confocal/methods Mitogen-Activated Protein Kinase 7/*genetics/*metabolism Neurogenesis Neurons/metabolism Odorants Olfactory Bulb/*metabolism Phen;" |
| Notes: | "MedlinePan, Yung-Wei Kuo, Chay T Storm, Daniel R Xia, Zhengui eng P30 HD02274/HD/NICHD NIH HHS/ T32 HD007183/HD/NICHD NIH HHS/ P30 HD002274/HD/NICHD NIH HHS/ F31 DC011216/DC/NIDCD NIH HHS/ DC004156/DC/NIDCD NIH HHS/ F31DC011216/DC/NIDCD NIH HHS/ T32HD007183/HD/NICHD NIH HHS/ R01 NS078192/NS/NINDS NIH HHS/ MH095840/MH/NIMH NIH HHS/ R01 DC004156/DC/NIDCD NIH HHS/ R01 MH095840/MH/NIMH NIH HHS/ Research Support, N.I.H., Extramural 2012/11/28 PLoS One. 2012; 7(11):e49622. doi: 10.1371/journal.pone.0049622. Epub 2012 Nov 21" |
