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Toxicol Lett

Title:		Environmental chemicals relevant for respiratory hypersensitivity: the indoor environment
Author(s):		Becher R; Hongslo JK; Jantunen MJ; Dybing E;
Address:		"National Institute of Public Health, Department of Environmental Medicine, Oslo, Norway"
Journal Title:		Toxicol Lett
Year:		1996
Volume:		86
Issue:		2-Mar
Page Number:		155 - 162
DOI:		10.1016/0378-4274(96)03685-5
ISSN/ISBN:		0378-4274 (Print) 0378-4274 (Linking)
Abstract:		"The allergenic constituents of non-industrial indoor environments are predominantly found in the biologic fraction. Several reports have related biological particles such as mites and their excreta, dander from pets and other furred animals, fungi and bacteria to allergic manifestations including respiratory hypersensitivity among the occupants of buildings. Also, bacterial cell-wall components and the spores of toxin-producing moulds may contribute to the induction of hypersensitivity, but the relevance for human health is not yet determined. The knowledge regarding hypersensitivity and asthmatic reactions after exposure to chemical agents is primarily based on data from occupational settings with much higher exposure levels than usually found in non-industrial indoor environments. However, there is evidence that indoor exposure to tobacco smoke, some volatile organic compounds (VOC) and various combustion products (either by using unvented stoves or from outdoor sources) can be related to asthmatic symptoms. In some susceptible individuals, the development of respiratory hypersensitivity or elicitation of asthmatic symptoms may also be related to the indiscriminate use of different household products followed by exposure to compounds such as diisocyanates, organic acid anhydrides, formaldehyde, styrene and hydroquinone. At present, the contribution of the indoor environment both to the development of respiratory hypersensitivity and for triggering asthmatic symptoms is far from elucidated"
Keywords:		"Air Pollution, Indoor/*adverse effects Allergens/adverse effects Asthma/etiology Environmental Exposure/*adverse effects Hazardous Substances/*adverse effects Humans Hydrocarbons/adverse effects/immunology Respiratory Hypersensitivity/*etiology Respirator;"
Notes:		"MedlineBecher, R Hongslo, J K Jantunen, M J Dybing, E eng Review Netherlands 1996/08/01 Toxicol Lett. 1996 Aug; 86(2-3):155-62. doi: 10.1016/0378-4274(96)03685-5"