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Int J Mol Sci

Title:		Microbiota and Malodor-Etiology and Management
Author(s):		Mogilnicka I; Bogucki P; Ufnal M;
Address:		"Department of Experimental Physiology and Pathophysiology, Laboratory of the Centre for Preclinical Research, Medical University of Warsaw, 02-091 Warsaw, Poland. Bristol Dermatology Centre, University Hospitals Bristol, Bristol BS2 8HW, UK"
Journal Title:		Int J Mol Sci
Year:		2020
Volume:		20200420
Issue:		8
Page Number:		-
DOI:		10.3390/ijms21082886
ISSN/ISBN:		1422-0067 (Electronic) 1422-0067 (Linking)
Abstract:		"Accumulating evidence indicates that microbiota plays a critical role in physiological processes in humans. However, it might also contribute to body malodor by producing numerous odorous molecules such as ammonia, volatile sulfur compounds or trimethylamine. Although malodor is commonly overlooked by physicians, it constitutes a major problem for many otherwise healthy people. Thus, this review aims to investigate most common causes of malodor and describe potential therapeutic options. We searched PUBMED and Google Scholar databases to identify the clinical and pre-clinical studies on bad body smell, malodor, halitosis and microbiota. Unpleasant smell might originate from the mouth, skin, urine or reproductive fluids and is usually caused by odorants that are produced by resident bacterial flora. The accumulation of odorous compounds might result from diet, specific composition of microbiota, as well as compromised function of the liver, intestines and kidneys. Evidence-based guidelines for management of body malodor are lacking and no universal treatment exists. However, the alleviation of the symptoms may be achieved by controlling the diet and physical elimination of bacteria and/or accumulated odorants"
Keywords:		Animals Bacteria/metabolism Body Fluids Dysbiosis Gastrointestinal Microbiome Halitosis/diagnosis/etiology/therapy Host-Pathogen Interactions Humans Methylamines/metabolism/urine *Microbiota *Odorants Saliva/microbiology Sulfur Compounds/metabolism/urine;
Notes:		"MedlineMogilnicka, Izabella Bogucki, Pawel Ufnal, Marcin eng 1S7/N/Warszawski Uniwersytet Medyczny/ Review Switzerland 2020/04/25 Int J Mol Sci. 2020 Apr 20; 21(8):2886. doi: 10.3390/ijms21082886"