| Title: | Levels of selected analytes in the emissions of 'heat not burn' tobacco products that are relevant to assess human health risks |
| Author(s): | Mallock N; Boss L; Burk R; Danziger M; Welsch T; Hahn H; Trieu HL; Hahn J; Pieper E; Henkler-Stephani F; Hutzler C; Luch A; |
| Address: | "German Federal Institute for Risk Assessment (BfR), Department of Chemical and Product Safety, Berlin, Germany. Nadja.Mallock@bfr.bund.de. German Federal Institute for Risk Assessment (BfR), Department of Chemical and Product Safety, Berlin, Germany. Official Chemical and Veterinary Surveillance Institute Sigmaringen, Sigmaringen, Germany" |
| DOI: | 10.1007/s00204-018-2215-y |
| ISSN/ISBN: | 1432-0738 (Electronic) 0340-5761 (Print) 0340-5761 (Linking) |
| Abstract: | "Consumers of combustible cigarettes are exposed to many different toxicologically relevant substances associated with negative health effects. Newly developed 'heat not burn' (HNB) devices are able to contain lower levels of Harmful and Potentially Harmful Constituents (HPHCs) in their emissions compared to tobacco cigarettes. However, to develop toxicological risk assessment strategies, further independent and standardized investigations addressing HPHC reduction need to be done. Therefore, we generated emissions of a commercially available HNB product following the Health Canada Intense smoking regimen and analyzed total particulate matter (TPM), nicotine, water, aldehydes, and other volatile organic compounds (VOCs) that are major contributors to health risk. We show that nicotine yield is comparable to typical combustible cigarettes, and observe substantially reduced levels of aldehydes (approximately 80-95%) and VOCs (approximately 97-99%). Emissions of TPM and nicotine were found to be inconsistent during the smoking procedure. Our study confirms that levels of major carcinogens are markedly reduced in the emissions of the analyzed HNB product in relation to the conventional tobacco cigarettes and that monitoring these emissions using standardized machine smoking procedures generates reliable and reproducible data which provide a useful basis to assess exposure and human health risks" |
| Keywords: | Air Pollutants/*adverse effects/analysis Canada Hot Temperature Nicotine/*adverse effects/analysis Particulate Matter/*adverse effects/analysis Risk Assessment Smoke/*adverse effects/analysis *Tobacco Products Volatile Organic Compounds/*adverse effects/a; |
| Notes: | "MedlineMallock, Nadja Boss, Lisa Burk, Robert Danziger, Martin Welsch, Tanja Hahn, Harald Trieu, Hai-Linh Hahn, Jurgen Pieper, Elke Henkler-Stephani, Frank Hutzler, Christoph Luch, Andreas eng Letter Germany 2018/05/08 Arch Toxicol. 2018 Jun; 92(6):2145-2149. doi: 10.1007/s00204-018-2215-y. Epub 2018 May 5" |
