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Reprod Nutr Dev

Title:		[Animal models of post-menopausal osteoporosis]
Author(s):		Barlet JP; Coxam V; Davicco MJ; Gaumet N;
Address:		"INRA-Theix, metabolisme mineral et osteogenese, croissance et metabolismes des herbivores, Saint-Genes-Champanelle, France"
Journal Title:		Reprod Nutr Dev
Year:		1994
Volume:		34
Issue:		3
Page Number:		221 - 236
DOI:
ISSN/ISBN:		0926-5287 (Print) 0926-5287 (Linking)
Abstract:		"Osteoporosis is a disease characterized by low bone mass, microarchitectural deterioration of bone tissue leading to enhanced bone fragility, and a consequent increase in fracture risk. In humans estrogen deficiency following menopause is associated with a more or less intense osteopenia. In some subjects, such a decrease in bone mass induces osteoporosis. Several animal models (ovariectomized female dogs, pigs and monkeys) are used to study the etiology, prophylaxis and treatment for osteoporosis. Nevertheless, the changes in bone metabolism following estrogen deficiency are very similar in rats and humans. Thus, the ovariectomized rat is the most frequently used model for such studies"
Keywords:		"Animals *Disease Models, Animal Dogs Female Haplorhini Humans Mice *Osteoporosis, Postmenopausal/etiology/prevention & control/therapy *Ovariectomy Rats Sheep Swine;"
Notes:		"MedlineBarlet, J P Coxam, V Davicco, M J Gaumet, N fre Comparative Study English Abstract Review France 1994/01/01 Reprod Nutr Dev. 1994; 34(3):221-36"