| Title: | Increased dopamine level enhances male-male courtship in Drosophila |
| Author(s): | Liu T; Dartevelle L; Yuan C; Wei H; Wang Y; Ferveur JF; Guo A; |
| Address: | "Institute of Neuroscience, State Key Laboratory of Neuroscience, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China" |
| DOI: | 10.1523/JNEUROSCI.5290-07.2008 |
| ISSN/ISBN: | 1529-2401 (Electronic) 0270-6474 (Print) 0270-6474 (Linking) |
| Abstract: | "Sexual behavior between males is observed in many species, but the biological factors involved are poorly known. In mammals, manipulation of dopamine has revealed the role of this neuromodulator on male sexual behavior. We used genetic and pharmacological approaches to manipulate the dopamine level in dopaminergic cells in Drosophila and investigated the consequence of this manipulation on male-male courtship behavior. Males with increased dopamine level showed enhanced propensity to court other males but did not change their courtship toward virgin females, general olfactory response, general gustatory response, or locomotor activity. Our results indicate that the high intensity of male-male interaction shown by these manipulated males was related to their altered sensory perception of other males" |
| Keywords: | "Analysis of Variance Animals Animals, Genetically Modified Avoidance Learning/physiology Behavior, Animal Choline O-Acetyltransferase *Courtship Dopamine/*metabolism Drosophila Drosophila Proteins/genetics Female Gene Expression Regulation Green Fluoresce;neuroscience;" |
| Notes: | "MedlineLiu, Tong Dartevelle, Laurence Yuan, Chunyan Wei, Hongping Wang, Ying Ferveur, Jean-Francois Guo, Aike eng Research Support, Non-U.S. Gov't 2008/05/23 J Neurosci. 2008 May 21; 28(21):5539-46. doi: 10.1523/JNEUROSCI.5290-07.2008" |
