| Title: | Microfabricated porous layer open tubular (PLOT) column |
| Author(s): | Li MW; She J; Zhu H; Li Z; Fan X; |
| Address: | "Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109, USA. xsfan@umich.edu and Center for Wireless Integrated MicroSensing and Systems (WIMS2), University of Michigan, Ann Arbor, MI 48109, USA and Department of Electrical Engineering and Computer Science, University of Michigan, Ann Arbor, MI 48109, USA. Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109, USA. xsfan@umich.edu and Center for Wireless Integrated MicroSensing and Systems (WIMS2), University of Michigan, Ann Arbor, MI 48109, USA. Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109, USA. xsfan@umich.edu and School of Precision Instruments and Opto-electronics Engineering, Tianjin University, P. R. China" |
| ISSN/ISBN: | 1473-0189 (Electronic) 1473-0189 (Linking) |
| Abstract: | "Development of micro gas chromatography (muGC) is aimed at rapid and in situ analysis of volatile organic compounds (VOCs) for environmental protection, industrial monitoring, and toxicology. However, due to the lack of appropriate microcolumns and associated stationary phases, current muGC is unable to separate highly volatile chemicals such as methane, methanol, and formaldehyde, which are of great interest for their high toxicity and carcinogenicity. This inability has significantly limited muGC field applicability. To address this deficiency, this paper reports the development and characterization of a microfabricated porous layer open tubular (muPLOT) column with a divinylbenzene-based stationary phase. The separation capabilities of the muPLOT column are demonstrated by three distinct analyses of light alkanes, formaldehyde solution, and organic solvents, exhibiting its general utility for a wide range of highly volatile compounds. Further characterization shows the robust performance of the muPLOT column in the presence of high moisture and at high temperatures (up to 300 degrees C). The small footprint and the ability to separate highly volatile chemicals make the muPLOT column highly suitable for integration into muGC systems, thus significantly broadening muGC's applicability to rapid, field analysis of VOCs" |
| Keywords: | "Chromatography, Gas/instrumentation *Microtechnology/instrumentation Particle Size Porosity Surface Properties Volatile Organic Compounds/*analysis;" |
| Notes: | "MedlineLi, Maxwell Wei-Hao She, Jinyan Zhu, Hongbo Li, Ziqi Fan, Xudong eng R01 OH011082/OH/NIOSH CDC HHS/ Research Support, U.S. Gov't, P.H.S. England 2019/10/30 Lab Chip. 2019 Dec 7; 19(23):3979-3987. doi: 10.1039/c9lc00886a. Epub 2019 Oct 29" |
