| Title: | Analyses of short-chain fatty acids and exhaled breath volatiles in dietary intervention trials for metabolic diseases |
| Address: | "Department of Human Sciences, The Ohio State University, Columbus, OH 43210, USA. James Comprehensive Cancer Center, The Ohio State University, Columbus, OH 43210, USA" |
| ISSN/ISBN: | 1535-3699 (Electronic) 1535-3702 (Print) 1535-3699 (Linking) |
| Abstract: | "As an alternative to pharmacological treatment to diseases, lifestyle interventions, such as dietary changes and physical activities, can help maintain healthy metabolic conditions. Recently, the emerging analyses of volatile organic compounds (VOCs) from breath and short-chain fatty acids (SCFAs) from plasma/feces have been considered as useful tools for the diagnosis and mechanistic understanding of metabolic diseases. Furthermore, diet-induced changes of SCFAs in individuals with diagnosed metabolic abnormalities have been correlated with the composition changes of the gut microbiome. More interestingly, the analysis of exhaled breath (breathomics) has gained attention as a useful technique to measure the human VOC profile altered as a result of dietary interventions. In this mini-review, we examined recent clinical trials that performed promising dietary interventions, SCFAs analysis in plasma/feces, and VOC profile analysis in exhaling breath to understand the relationship between dietary intervention and metabolic health" |
| Keywords: | "Diet Exercise/physiology Exhalation/*physiology Fatty Acids, Volatile/*metabolism Gastrointestinal Microbiome/*drug effects/physiology Humans Metabolic Diseases/*drug therapy/metabolism Volatile Organic Compounds/*pharmacology Dietary intervention breatho;" |
| Notes: | "MedlineLee, Jisun Hj Zhu, Jiangjiang eng R35 GM133510/GM/NIGMS NIH HHS/ Research Support, N.I.H., Extramural England 2020/12/18 Exp Biol Med (Maywood). 2021 Apr; 246(7):778-789. doi: 10.1177/1535370220979952. Epub 2020 Dec 16" |
