| Title: | Comparative analysis of urban road dust compositions in relation to their potential human health impacts |
| Address: | "Bio Platform Technology Research Center, Korea Research Institute of Chemical Technology, 141 Gajeong-ro, Yuseong-gu, Daejeon 34114, Republic of Korea. Electronic address: bkoh@krict.re.kr. Chemical Safety Research Center, Korea Research Institute of Chemical Technology, 141 Gajeong-ro, Yuseong-gu, Daejeon 34114, Republic of Korea; National Assembly Futures Institute, Member's Office Bldg, 1 Uisadang-daero, Yeongdeungpo-gu, Seoul 07233, Republic of Korea. Electronic address: eakim@nafi.re.kr" |
| DOI: | 10.1016/j.envpol.2019.113156 |
| ISSN/ISBN: | 1873-6424 (Electronic) 0269-7491 (Linking) |
| Abstract: | "This study investigated the chemical components of fine urban road dust from seven sampling sites, based on which we could predict potential human health effects. The elemental compositions, including the contents of metals and volatile or semivolatile organic compounds, were determined to establish comprehensive chemical profiles of solid road dust. The chemical profiles, consisting of C: H ratio, metal contents, and relative abundances of organic compounds, provided a chemical signature for road dust. To overall cytotoxicity values ranging between 7 and 58%, water extracts contributed less than 15%, and cell death mainly occurred via direct contact with solid-phase components, which possibly indicates that the selected chemical profile of solid-phase road dust components could serve as a strong predictor for BJ and WI-38 cytotoxicity. Pure metal oxides (Cr(2)O(3), CuO, Fe(2)O(3), MnO(2), NiO, or ZnO) exhibited a positive dose-response, and the corresponding metal contents in solid road dust were well correlated with cell viability. The principal component analysis (PCA) results suggested that the metal contents were stronger predictors of cytotoxicity than the benzene derivative or hydrocarbon contents. The chemical profiles established in this study could be further utilized to identify candidate health hazard factors in road dust" |
| Keywords: | Dust/*analysis *Environmental Monitoring Environmental Pollutants/*analysis Humans Manganese Compounds/analysis Metals/analysis Oxides/analysis Benzene derivative Cytotoxicity Hydrocarbon Metal oxide Principal component analysis Road dust; |
| Notes: | "MedlineKoh, Byumseok Kim, Eun-Ah eng England 2019/09/30 Environ Pollut. 2019 Dec; 255(Pt 2):113156. doi: 10.1016/j.envpol.2019.113156. Epub 2019 Sep 3" |
