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Environ Toxicol Pharmacol

Title:		Household tobacco smoke exposure and acrylonitrile metabolite levels in a US pediatric sample
Author(s):		Kindilien S; Goldberg E;
Address:		"College of Pharmacy, University of New Mexico, 2502 Marble Ave, Albuquerque, NM, 87106, United States. Electronic address: skindili@salud.unm.edu. Quality Outcomes, Outcomes Research Team, The University of New Mexico Hospital, 933 Bradbury Dr SE, Albuquerque, NM, 87106, United States. Electronic address: emgoldberg@salud.unm.edu"
Journal Title:		Environ Toxicol Pharmacol
Year:		2021
Volume:		20210217
Issue:
Page Number:		103616 -
DOI:		10.1016/j.etap.2021.103616
ISSN/ISBN:		1872-7077 (Electronic) 1382-6689 (Linking)
Abstract:		"This study seeks to determine if members of a pediatric (<18 years) sample who have high levels of the urinary volatile organic compound (VOC) metabolite of acrylonitrile, N-Acetyl-S-(2-cyanoethyl)-l-cysteine (CYMA), are significantly more likely to be living in a household with indoor tobacco smoke exposure. A weighted logistic regression was used to compare pediatric participants in the highest quartile of CYMA levels (>/= 4.56 ng/mL) with those whose CYMA levels were not in the highest quartile. 411 pediatric participants were identified in the NHANES data for analysis. Those in the highest quartile of recorded CYMA values were more likely to be living with active indoor smokers (69.35 %) than those who were not in the highest quartile (32.72 %). Having one indoor smoker (adjusted-OR: 2.53, 95 % CI: 1.01-6.34) or 2+ indoor smokers (adjusted-OR: 4.25, 95 % CI: 1.84-9.81) were both associated with a pediatric participant having a CYMA value in the highest quartile"
Keywords:		"Acetylcysteine/*analogs & derivatives/urine *Acrylonitrile Adolescent *Air Pollutants Biological Monitoring Child Child, Preschool Female Housing Humans *Inhalation Exposure Male Nutrition Surveys *Tobacco Smoke Pollution Acrylonitrile Nhanes Tobacco expo;"
Notes:		"MedlineKindilien, Shannon Goldberg, Elle eng Netherlands 2021/02/21 Environ Toxicol Pharmacol. 2021 May; 84:103616. doi: 10.1016/j.etap.2021.103616. Epub 2021 Feb 17"