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Toxicol In Vitro

Title:		The biological and toxicological activity of gases and vapors
Author(s):		Abraham MH; Sanchez-Moreno R; Gil-Lostes J; Acree WE; Cometto-Muniz JE; Cain WS;
Address:		"Department of Chemistry, University College London, 20 Gordon Street, London WC1H OAJ, UK. m.h.abraham@ucl.ac.uk"
Journal Title:		Toxicol In Vitro
Year:		2010
Volume:		20091112
Issue:		2
Page Number:		357 - 362
DOI:		10.1016/j.tiv.2009.11.009
ISSN/ISBN:		1879-3177 (Electronic) 0887-2333 (Print) 0887-2333 (Linking)
Abstract:		"A large amount of data on the biological and toxicological activity of gases and vapors has been collected from the literature. Processes include sensory irritation thresholds, the Alarie mouse test, inhalation anesthesia, etc. It is shown that a single equation using only five descriptors (properties of the gases and vapors) plus a set of indicator variables for the given processes can correlate 643 biological and non-lethal toxicological activities of 'non-reactive' compounds with a standard deviation of 0.36 log unit. The equation is scaled to sensory irritation thresholds obtained by the procedure of Cometto-Muniz, and Cain provides a general equation for the prediction of sensory irritation thresholds in man. It is suggested that differences in biological/toxicological activity arise primarily from transport from the gas phase to a receptor phase or area, except for odor detection thresholds where interaction with a receptor(s) is important"
Keywords:		"Animals Eye Diseases/chemically induced Gases/*toxicity Humans *Models, Biological Volatile Organic Compounds/*toxicity;"
Notes:		"MedlineAbraham, Michael H Sanchez-Moreno, Ricardo Gil-Lostes, Javier Acree, William E Jr Cometto-Muniz, J Enrique Cain, William S eng DC 002741/DC/NIDCD NIH HHS/ R01 DC005003-04/DC/NIDCD NIH HHS/ R01 DC005003/DC/NIDCD NIH HHS/ R29 DC002741/DC/NIDCD NIH HHS/ R01 DC002741/DC/NIDCD NIH HHS/ R01 DC002741-14/DC/NIDCD NIH HHS/ R01 DC 005003/DC/NIDCD NIH HHS/ Research Support, N.I.H., Extramural England 2009/11/17 Toxicol In Vitro. 2010 Mar; 24(2):357-62. doi: 10.1016/j.tiv.2009.11.009. Epub 2009 Nov 12"