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Anal Bioanal Chem

Title:		A comparison of three solvent-free techniques coupled with gas chromatography for determining trihalomethanes in urine samples
Author(s):		Jakubowska N; Polkowska Z; Kujawski W; Konieczka P; Namiesnik J;
Address:		"Department of Analytical Chemistry, Chemical Faculty, Gdansk University of Technology (GUT), 11/12 G. Narutowicza Street, 80-952, Gdansk, Poland. chemanal@pg.gda.pl"
Journal Title:		Anal Bioanal Chem
Year:		2007
Volume:		20070417
Issue:		3
Page Number:		691 - 698
DOI:		10.1007/s00216-007-1259-2
ISSN/ISBN:		1618-2650 (Electronic) 1618-2642 (Linking)
Abstract:		"The analysis of volatile organic compounds in samples of biological fluids characterized by complex matrices is highly challenging. This paper presents a comparison of the results obtained in this field using three solvent-free techniques: thin-layer headspace with autogenous generation of liquid sorbent (TLHS) and membrane separation of the trace substances (pervaporation, PV), both of which are coupled to direct aqueous injection gas chromatography-electron capture detection (TLHS-DAI-GC-ECD and PV-DAI-GC-ECD), as well as conventional static headspace analysis followed by GC analysis with ECD detection (HS-GC-ECD). Basic validation parameters of the HS-GC-ECD, TLHS-DAI-GC-ECD and PV-DAI-GC-ECD procedures were calculated for water and urine samples. The calibration curves for all procedures were linear within the concentration range examined. The intermediate precisions of the procedures were good and reached about 10% (for all analytes) for HS-GC-ECD and TLHS-DAI-GC-ECD. The poorest results were obtained for PV-DAI-GC-ECD: about 20% for all analytes. The lowest method detection limits were obtained for the TLHS-DAI-GC-ECD procedure: below 0.0022 microg/L for all analytes. The enrichment factors did not differ significantly between water and urine samples, indicating little or no matrix effect in all procedures"
Keywords:		"Calibration Chromatography, Gas/*methods Environmental Pollutants/*urine Humans Reference Standards Reproducibility of Results Sensitivity and Specificity Solvents Trihalomethanes/*urine Volatilization;"
Notes:		"MedlineJakubowska, Natalia Polkowska, Zaneta Kujawski, Wojciech Konieczka, Piotr Namiesnik, Jacek eng Comparative Study Germany 2007/04/18 Anal Bioanal Chem. 2007 Jun; 388(3):691-8. doi: 10.1007/s00216-007-1259-2. Epub 2007 Apr 17"