| Title: | Noninvasive Diagnosis of Gastric Cancer Based on Breath Analysis with a Tubular Surface-Enhanced Raman Scattering Sensor |
| Author(s): | Huang L; Zhu Y; Xu C; Cai Y; Yi Y; Li K; Ren X; Jiang D; Ge Y; Liu X; Sun W; Zhang Q; Wang Y; |
| Address: | "School of Biomedical Engineering, School of Ophthalmology and Optometry, Eye Hospital, Wenzhou Medical University, Wenzhou, 325001, PR China. Engineering Research Center of Clinical Functional Materials and Diagnosis & Treatment Devices of Zhejiang Province, Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou, 325001, PR China. Department of Gastrointestinal Surgery, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325027, PR China" |
| DOI: | 10.1021/acssensors.2c00146 |
| ISSN/ISBN: | 2379-3694 (Electronic) 2379-3694 (Linking) |
| Abstract: | "SERS-based breath analysis as an emerging technique has attracted increasing attention in cancer screening. Here, eight aldehydes and ketones in the human breath are reported as the VOC biomarkers identified by gas chromatography-mass spectrometry (GC-MS) and applied further for the noninvasive diagnosis of gastric cancer (GC) with a tubular SERS sensor. The tubular SERS sensor is prepared with a glass capillary loaded with ZIF-67-coated silver particles (Ag@ZIF-67), which offers Raman enhancement from the plasmonic nanoparticles and gas enrichment from the metal-organic framework (MOF) shells. The composite materials are modified with 4-aminothiophenol (4-ATP) to capture different aldehyde and ketone compounds. The tubular sensor is served simultaneously as a gas flow channel and a detection chamber, bringing a higher gas capture efficiency than the planar SERS sensor. As a proof-of-concept, the tubular SERS sensor is successfully employed to screen gastric cancer patients with an accuracy of 89.83%, based on the noninvasive, rapid, and easily operated breath analysis. The results demonstrate that the established breath analysis method provides an excellent alternative for the screening of GC and other diseases" |
| Keywords: | "Breath Tests Humans *Metal Nanoparticles Silver/chemistry Spectrum Analysis, Raman *Stomach Neoplasms/diagnosis breath analysis gastric cancer noninvasive diagnosis surface-enhanced Raman scattering (SERS) volatile organic compounds (VOCs);" |
| Notes: | "MedlineHuang, Liping Zhu, Yajie Xu, Changshun Cai, Yu Yi, Yongdong Li, Kang Ren, Xueqian Jiang, Danfeng Ge, Yuancai Liu, Xiaohu Sun, Weijian Zhang, Qingwen Wang, Yi eng Research Support, Non-U.S. Gov't 2022/05/14 ACS Sens. 2022 May 27; 7(5):1439-1450. doi: 10.1021/acssensors.2c00146. Epub 2022 May 13" |
