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Contact Dermatitis

Title:		"Occupational airborne contact urticaria, anaphylaxis and asthma in farmers and agronomists due to Bruchus pisorum"
Author(s):		Armentia A; Alvarez R; Moreno-Gonzalez V; Martin B; Fernandez S; Martin S; Moro A; Vega JM; Barrios A; Castillo M; Pineda F;
Address:		"Allergy Unit, Hospital Universitario Rio Hortega, Valladolid, Spain. Departamento de Biologia Molecular, Area de Biologia Celular, Universidad de Leon, Leon, Spain. Departamento de Biodiversidad y Gestion Ambiental, Area de Zoologia, Universidad de Leon, Leon, Spain. ITACYL, Consejeria de Agricultura de Castilla y Leon, Leon, Spain. Allergy Unit, Laboratorios DIATER, Madrid, Spain"
Journal Title:		Contact Dermatitis
Year:		2020
Volume:		20200805
Issue:		6
Page Number:		466 - 474
DOI:		10.1111/cod.13644
ISSN/ISBN:		1600-0536 (Electronic) 0105-1873 (Linking)
Abstract:		"BACKGROUND: Occupational contact urticaria due to inhalation of legume pest allergens has rarely been described. OBJECTIVE: To determine the cause of an outbreak of airborne contact urticaria, asthma, and anaphylaxis in farmers and agronomists studying the disinsectization of dried peas. Peas were treated with aluminum phosphide (EPA). METHODS: Extracts prepared from Bruchus lentis and Bruchus pisorum bodies and from healthy legumes, EPA-treated legumes, and infested legumes, were used for in vivo tests (skin prick testing, oral, and specific bronchial challenge for the diagnosis of asthma and anaphylaxis) in affected patients and in five control patients with severe legume hypersensitivity. Open application, patch testing with the most common legume insecticides, molecular analysis, and IgE immunoblotting were undertaken. RESULTS: We found positive responses (prick, provocation, immune detection) to parasitic pea extracts and B. pisorum. A 25 kDa band was detected in the western blot of all patients who worked with infested EPA-treated peas. Bands from B. pisorum extract were detected in all patients. No responses to pea allergens were found in any patient, unlike in legume allergy controls. Oral provocation tests were negative. CONCLUSION: B. pisorum is a cause of contact urticaria and may cause occupational hives, anaphylaxis, and asthma. The allergen may enter by inhalation or puncture of setae released by B. pisorum"
Keywords:		"Adult Anaphylaxis/diagnosis/*etiology Asthma/chemically induced/*diagnosis Dermatitis, Allergic Contact/*diagnosis/etiology Fabaceae/*adverse effects Farmers/*statistics & numerical data Female Food Hypersensitivity/etiology Humans Immunoglobulin E/immuno;"
Notes:		"MedlineArmentia, Alicia Alvarez, Rafael Moreno-Gonzalez, Victor Martin, Blanca Fernandez, Sara Martin, Sara Moro, Angela Vega, Jose M Barrios, Abel Castillo, Miriam Pineda, Fernando eng England 2020/06/28 Contact Dermatitis. 2020 Dec; 83(6):466-474. doi: 10.1111/cod.13644. Epub 2020 Aug 5"