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Exp Parasitol

Title:		Correlation of radical-scavenging capacity and amoebicidal activity of Matricaria recutita L. (Asteraceae)
Author(s):		Hajaji S; Sifaoui I; Lopez-Arencibia A; Reyes-Batlle M; Jimenez IA; Bazzocchi IL; Valladares B; Pinero JE; Lorenzo-Morales J; Akkari H;
Address:		"Laboratoire de Parasitologie, Universite de la Manouba, Ecole Nationale de Medecine Veterinaire de Sidi thabet, 2020, Tunisia; Faculte des sciences de Bizerte, Universite de Carthage, 7021, Zarzouna, Tunisia. Electronic address: soumayahajjaji86@gmail.com. Laboratoire Materiaux-Molecules et Applications, IPEST, University of Carthage, La Marsa, Tunisia; University Institute of Tropical Diseases and Public Health of the Canary Islands, University of La Laguna, Avda. Astrofisico Fco. Sanchez, La Laguna, Tenerife, Canary Islands, Spain. University Institute of Tropical Diseases and Public Health of the Canary Islands, University of La Laguna, Avda. Astrofisico Fco. Sanchez, La Laguna, Tenerife, Canary Islands, Spain. Instituto Universitario de Bio-Organica Antonio Gonzalez, Department of Organic Chemistry, Universidad de La Laguna, Tenerife, Canary Islands, Spain. Laboratoire de Parasitologie, Universite de la Manouba, Ecole Nationale de Medecine Veterinaire de Sidi thabet, 2020, Tunisia"
Journal Title:		Exp Parasitol
Year:		2017
Volume:		20170914
Issue:
Page Number:		212 - 217
DOI:		10.1016/j.exppara.2017.09.011
ISSN/ISBN:		1090-2449 (Electronic) 0014-4894 (Linking)
Abstract:		"Some Acanthamoeba strains are able to cause Granulomatous Amoebic Encephalitis (GAE) and Acanthamoeba keratitis (AK) worldwide because of their pathogenicity. The treatment of Acanthamoeba infections is complicated due to the existence of a highly resistant cyst stage in their life cycle. Therefore, the elucidation of novel sources of anti-Acanthamoeba agents is an urgent need. In the present study, an evaluation of the antioxidant and anti-Acanthamoeba activity of compounds in flower extracts of Tunisian chamomile (Matricaria recutita L.) was carried out. Chamomile methanol extract was the most active showing an IC(50) of 66.235 +/- 0.390 mug/ml, low toxicity levels when checked in murine macrophage toxicity model and presented also antioxidant properties. Moreover, a bio-guided fractionation of this extract was developed and led to the identification of a mixture of coumarins as the most active fraction. These results suggest a novel source of anti-Acanthamoeba compounds for the development of novel therapeutic agents against Acanthamoeba infections"
Keywords:		"Acanthamoeba castellanii/*drug effects Amebicides/chemistry/isolation & purification/*pharmacology Animals Biological Assay Cell Line Chromatography, Thin Layer Coumarins/chemistry/pharmacology Flowers/chemistry Free Radical Scavengers/chemistry/isolation;"
Notes:		"MedlineHajaji, Soumaya Sifaoui, Ines Lopez-Arencibia, Atteneri Reyes-Batlle, Maria Jimenez, Ignacio A Bazzocchi, Isabel L Valladares, Basilio Pinero, Jose E Lorenzo-Morales, Jacob Akkari, Hafidh eng 2017/09/19 Exp Parasitol. 2017 Dec; 183:212-217. doi: 10.1016/j.exppara.2017.09.011. Epub 2017 Sep 14"