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Proc Natl Acad Sci U S A

Title:		Generalized singular value decomposition for comparative analysis of genome-scale expression data sets of two different organisms
Author(s):		Alter O; Brown PO; Botstein D;
Address:		"Department of Genetics, Stanford University, Stanford, CA 94305. orly@genome.stanford.edu"
Journal Title:		Proc Natl Acad Sci U S A
Year:		2003
Volume:		20030311
Issue:		6
Page Number:		3351 - 3356
DOI:		10.1073/pnas.0530258100
ISSN/ISBN:		0027-8424 (Print) 1091-6490 (Electronic) 0027-8424 (Linking)
Abstract:		"We describe a comparative mathematical framework for two genome-scale expression data sets. This framework formulates expression as superposition of the effects of regulatory programs, biological processes, and experimental artifacts common to both data sets, as well as those that are exclusive to one data set or the other, by using generalized singular value decomposition. This framework enables comparative reconstruction and classification of the genes and arrays of both data sets. We illustrate this framework with a comparison of yeast and human cell-cycle expression data sets"
Keywords:		"Cell Cycle/genetics Data Interpretation, Statistical Databases, Genetic Gene Expression Profiling/*statistics & numerical data Genes, Fungal/drug effects Genomics/*statistics & numerical data Humans Oligonucleotide Array Sequence Analysis/statistics & num;"
Notes:		"MedlineAlter, Orly Brown, Patrick O Botstein, David eng U01 CA085129/CA/NCI NIH HHS/ R01 GM046406/GM/NIGMS NIH HHS/ R01 CA077097/CA/NCI NIH HHS/ 5K01 HG 00038-01/HG/NHGRI NIH HHS/ R37 GM046406/GM/NIGMS NIH HHS/ K01 HG000038/HG/NHGRI NIH HHS/ CA 85129/CA/NCI NIH HHS/ GM 46406/GM/NIGMS NIH HHS/ CA 77097/CA/NCI NIH HHS/ Comparative Study Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S. 2003/03/13 Proc Natl Acad Sci U S A. 2003 Mar 18; 100(6):3351-6. doi: 10.1073/pnas.0530258100. Epub 2003 Mar 11"