| Title: | Inter-individual variability in blood/air partitioning of volatile organic compounds and correlation with blood chemistry |
| Author(s): | Dills RL; Ackerlund WS; Kalman DA; Morgan MS; |
| Address: | "Department of Environmental Health School of Public Health and Community Medicine University of Washington, Seattle 98195, USA" |
| Journal Title: | J Expo Anal Environ Epidemiol |
| ISSN/ISBN: | 1053-4245 (Print) 1053-4245 (Linking) |
| Abstract: | "In vitro blood/air partition coefficients (KB/A) for acetone, 1,1,1-trichloroethane, toluene, and styrene were measured in blood samples from 73 human subjects and correlated with blood chemistry parameters (hematocrit, total cholesterol, serum triglycerides, serum albumin, total plasma proteins, Na+, K+, Cl-, and HCO3-). Statistically significant inter-individual variation existed in KB/A between some subjects. Substitution of group or generic in vitro KB/A values for values determined in some individuals could introduce errors of up to 50%. However, most subjects could be well represented by group averages (mean +/- SD; acetone, 301 +/- 22; 1,1,1-trichloroethane, 6.0 +/- 0.8; toluene, 19 +/- 3; styrene, 62 +/- 10). The KB/A values for acetone, 1,1,1-trichloroethane and toluene were normally distributed. The data for styrene appeared to deviate from a normal distribution and may have been bimodal. The KB/A values for the two structurally related compounds, toluene and styrene, were strongly correlated within individuals, while the KB/A values for compounds with less structural similarity, such as acetone and styrene, were poorly correlated. At most, 15% of the variation in KB/A among individuals could be explained by variation in the measured blood chemistry parameters. When the entire sample group was considered, blood chemistry parameters were not significantly correlated with KB/A for any compound. The KB/A of 1,1,1-trichloroethane was significantly correlated with the concentration of cholesterol and triglycerides in females. Sex was a significant grouping variable for the correlation of albumin concentration with the KB/A of styrene. Age was not a significant correlation variable. Blood chemistry parameters which previously have been correlated with KB/A in small sample groups do not appear to be significantly correlated in our larger sample group" |
| Keywords: | Acetone/blood/*pharmacokinetics Adolescent Adult Age Factors Benzene Derivatives/blood/*pharmacokinetics Blood-Air Barrier/*physiology Female Humans Male Regression Analysis Sex Factors Specimen Handling Time Factors Trichloroethanes/blood/*pharmacokineti; |
| Notes: | "MedlineDills, R L Ackerlund, W S Kalman, D A Morgan, M S eng ES 04696/ES/NIEHS NIH HHS/ Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. England 1994/04/01 J Expo Anal Environ Epidemiol. 1994 Apr-Jun; 4(2):229-45" |
