| Title: | Effects of indoor painting and smoking on airway symptoms in atopy risk children in the first year of life results of the LARS-study. Leipzig Allergy High-Risk Children Study |
| Author(s): | Diez U; Kroessner T; Rehwagen M; Richter M; Wetzig H; Schulz R; Borte M; Metzner G; Krumbiegel P; Herbarth O; |
| Address: | "Centre of Environmental Research, Department of Human Exposure Research and Epidemiology, Leipzig, Germany. diez@expo.ufz.de" |
| DOI: | 10.1078/s1438-4639(04)70004-8 |
| ISSN/ISBN: | 1438-4639 (Print) 1438-4639 (Linking) |
| Abstract: | "INTRODUCTION: The Leipzig Allergy High-Risk Children Study (LARS) is a prospective nested cohort control study about the influence of chemical indoor exposure in dwellings on the health outcome of atopy-risk children during the first years of life. DESIGN AND METHODS: 475 premature children and children with allergic risk factors have been selected out of the 1995/1996 birth cohort in the city of Leipzig. Twenty-five volatile organic compounds (VOC) were measured in the infant's bedrooms using passive sampling systems for 4 weeks after birth. The babies underwent a medical examination at the age of six weeks and 1 year. The parents answered a questionnaire. RESULTS: Correlations between VOC exposures and infections were calculated by multiple logistic regression. Selected VOC show a direct association to actually painted dwellings (OR = 2.4; 95% Cl 1.1-5.3). An increase of risk of pulmonary infections was observed in infants aged 6 weeks if restoration (painting OR 5.6; 95% Cl 1.3-24.0) or flooring connected with painting had occurred during the pregnancy period. Higher concentration of styrene (> 2.0 micrograms/m3, indicator for flooring) elevated the risk of pulmonary infections in six-week-old infants (OR = 2.1; 95% Cl 1.1-4.2). Environmental benzene > 5.6 micrograms/m3 increased the risk of airway infections in six-week-old babies (OR = 2.4; 95% Cl 1.28-4.48). Smoking in the dwelling (OR = 2.0; 95% Cl 1.1-3.5) as well as restoration (OR = 1.9; 95% Cl 1.1-3.5) are also risk factors of the development of wheezing in the one-year-old child. CONCLUSIONS: The data give indications in order to prevent allergies and chronic lung diseases in atopy risk children exposure to chemicals from indoor air should be minimised from birth on" |
| Keywords: | "Air Pollution, Indoor/*adverse effects Antibodies/blood Cohort Studies Dermatitis, Atopic/*genetics Environmental Exposure/*adverse effects Female Fetal Blood/immunology Germany/epidemiology Humans Immunoglobulin E/blood Infant Infant, Newborn Infant, Pre;" |
| Notes: | "MedlineDiez, U Kroessner, T Rehwagen, M Richter, M Wetzig, H Schulz, R Borte, M Metzner, G Krumbiegel, P Herbarth, O eng Germany 2000/08/24 Int J Hyg Environ Health. 2000 Mar; 203(1):23-8. doi: 10.1078/s1438-4639(04)70004-8" |
