| Title: | Sensitivity-Tunable Colorimetric Detection of Chloropicrin Vapor on Nylon-6 Nanofibrous Membrane Based on a Detoxification Reaction with Biological Thiols |
| Author(s): | Tang P; Leung HT; Gomez MT; Sun G; |
| DOI: | 10.1021/acssensors.8b00135 |
| ISSN/ISBN: | 2379-3694 (Electronic) 2379-3694 (Linking) |
| Abstract: | "Detoxification reaction of chloropicrin in the human body with biological thiols was selected for detection of chloropicrin in the air. The consumption of free sulfhydryl group in biological thiols by chloropicrin is colorimetrically detectable with the addition of the Ellman's reagent. In this study, glutathione, N-acetyl-l-cysteine, l-homocysteine, cysteamine, and thioglycolic acid were tested as sensing agents for chloropicrin vapor detection in ppb concentration range. The reactivity of the selected biological thiols was investigated based on both their redox properties and the nucleophilic strength of the sulfhydryl groups. Nylon-6 nanofibrous membrane and an organic solvent were used as a sensor matrix and a vapor sorbent, respectively, to provide solid supports with ultrahigh surface area and enhanced adsorption to chloropicrin vapor. The tunable sensitivity and detection range by using different biological thiols was achieved on the sensors due to the different reactivity of thiols toward chloropicrin" |
| Keywords: | "Caprolactam/*analogs & derivatives/chemistry/metabolism *Colorimetry/instrumentation Humans Hydrocarbons, Chlorinated/*analysis/metabolism Molecular Structure Nanofibers/*chemistry Polymers/*chemistry/metabolism Sulfhydryl Compounds/chemistry/*metabolism;" |
| Notes: | "MedlineTang, Peixin Leung, Ho Ting Gomez, Maria Trinidad Sun, Gang eng Research Support, Non-U.S. Gov't 2018/03/29 ACS Sens. 2018 Apr 27; 3(4):858-866. doi: 10.1021/acssensors.8b00135. Epub 2018 Apr 4" |
