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Bioorg Med Chem

Title:		Proteins that smell: pheromone recognition and signal transduction
Author(s):		Prestwich GD;
Address:		"Department of Chemistry, University at Stony Brook, NY 11794-3400, USA"
Journal Title:		Bioorg Med Chem
Year:		1996
Volume:		4
Issue:		3
Page Number:		505 - 513
DOI:		10.1016/0968-0896(96)00033-8
ISSN/ISBN:		0968-0896 (Print) 0968-0896 (Linking)
Abstract:		"Pheromone perception in Lepidoptera requires initial recognition and transport of the pheromone molecule by ligand-specific pheromone binding proteins (PBPs) in the moth antennae, followed by recognition of the ligand or PBP-ligand complex by a transmembrane G-protein-coupled odorant receptor protein. This signal is transduced by activation of a specific phospholipase C, intracellular release of inositol 1,4,5-trisphosphate (IP3) and IP3-gated opening of an ion channel. Individual pheromone-specific PBPs provide the initial ligand recognition event and encode ligand specificity. We have used photoaffinity labeling, cDNA library screening and cloning, protein expression, a novel binding assay and site-directed mutagenesis to define the ligand specificity of PBPs"
Keywords:		Amino Acid Sequence Animals Base Sequence Binding Sites Female Male Molecular Sequence Data Moths/*physiology Pheromones/genetics/*physiology Signal Transduction/*physiology Smell/*physiology Structure-Activity Relationship;
Notes:		"MedlinePrestwich, G D eng NS 29632/NS/NINDS NIH HHS/ Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S. Review England 1996/03/01 Bioorg Med Chem. 1996 Mar; 4(3):505-13. doi: 10.1016/0968-0896(96)00033-8"