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Chest

Title:		Update on Biomarkers for the Stratification of Indeterminate Pulmonary Nodules
Author(s):		Paez R; Kammer MN; Tanner NT; Shojaee S; Heideman BE; Peikert T; Balbach ML; Iams WT; Ning B; Lenburg ME; Mallow C; Yarmus L; Fong KM; Deppen S; Grogan EL; Maldonado F;
Address:		"Department of Medicine, Division of Allergy, Pulmonary and Critical Care Medicine, Vanderbilt University Medical Center, Nashville, TN. Department of Medicine, Division of Pulmonary, Critical Care, Allergy and Sleep Medicine, Medical University of South Carolina, Charleston, SC. Department of Medicine, Division of Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, MN. Department of Medicine, Vanderbilt University Medical Center, Nashville, TN. Department of Medicine, Division of Hematology-Oncology, Vanderbilt University Medical Center, Nashville, TN; Vanderbilt-Ingram Cancer Center, Nashville, TN. Department of Medicine, Section of Computational Biomedicine, Boston University School of Medicine, Boston, MA. Division of Pulmonary, Critical Care and Sleep Medicine, University of Miami, Miami, FL. Division of Pulmonary and Critical Care Medicine, Johns Hopkins University, Baltimore, MD. University of Queensland Thoracic Research Centre, The Prince Charles Hospital, Brisbane, QLD, Australia. Department of Thoracic Surgery, Vanderbilt University Medical Center, Nashville, TN; Vanderbilt-Ingram Cancer Center, Nashville, TN; Tennessee Valley Healthcare System, Nashville, TN. Department of Medicine, Division of Allergy, Pulmonary and Critical Care Medicine, Vanderbilt University Medical Center, Nashville, TN. Electronic address: fabien.maldonado@vumc.org"
Journal Title:		Chest
Year:		2023
Volume:		20230525
Issue:
Page Number:		-
DOI:		10.1016/j.chest.2023.05.025
ISSN/ISBN:		1931-3543 (Electronic) 0012-3692 (Linking)
Abstract:		"Lung cancer is the leading cause of cancer-related deaths. Early detection and diagnosis are critical, as survival decreases with advanced stages. Approximately 1.6 million nodules are incidentally detected every year on chest CT scan images in the United States. This number of nodules identified is likely much larger after accounting for screening-detected nodules. Most of these nodules, whether incidentally or screening detected, are benign. Despite this, many patients undergo unnecessary invasive procedures to rule out cancer because our current stratification approaches are suboptimal, particularly for intermediate probability nodules. Thus, noninvasive strategies are urgently needed. Biomarkers have been developed to assist through the continuum of lung cancer care and include blood protein-based biomarkers, liquid biopsies, quantitative imaging analysis (radiomics), exhaled volatile organic compounds, and bronchial or nasal epithelium genomic classifiers, among others. Although many biomarkers have been developed, few have been integrated into clinical practice as they lack clinical utility studies showing improved patient-centered outcomes. Rapid technologic advances and large network collaborative efforts will continue to drive the discovery and validation of many novel biomarkers. Ultimately, however, randomized clinical utility studies showing improved patient outcomes will be required to bring biomarkers into clinical practice"
Keywords:		biomarkers early detection indeterminate pulmonary nodules lung cancer;
Notes:		"PublisherPaez, Rafael Kammer, Michael N Tanner, Nicole T Shojaee, Samira Heideman, Brent E Peikert, Tobias Balbach, Meridith L Iams, Wade T Ning, Boting Lenburg, Marc E Mallow, Christopher Yarmus, Lonny Fong, Kwun M Deppen, Stephen Grogan, Eric L Maldonado, Fabien eng U01 CA152662/CA/NCI NIH HHS/ Review 2023/05/28 Chest. 2023 May 25:S0012-3692(23)00785-7. doi: 10.1016/j.chest.2023.05.025"