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Proc Natl Acad Sci U S A

Title:		Structural organization of the Helicoverpa zea gene encoding the precursor protein for pheromone biosynthesis-activating neuropeptide and other neuropeptides
Author(s):		Ma PW; Knipple DC; Roelofs WL;
Address:		"Department of Entomology, New York State Agricultural Experiment Station, Cornell University, Geneva 14456"
Journal Title:		Proc Natl Acad Sci U S A
Year:		1994
Volume:		91
Issue:		14
Page Number:		6506 - 6510
DOI:		10.1073/pnas.91.14.6506
ISSN/ISBN:		0027-8424 (Print) 1091-6490 (Electronic) 0027-8424 (Linking)
Abstract:		"Sex pheromone biosynthesis in a number of moth species is induced by a conserved 33-amino acid amidated neuropeptide PBAN (pheromone biosynthesis-activating neuropeptide). We have isolated and characterized the Helicoverpa zea PBAN cDNA corresponding to a 766-nucleotide mRNA that is expressed in the subesophageal ganglion of adult moths. This mRNA is encoded on a transcription unit comprising 6 exons. The longest open reading frame of the cDNA encodes a 194-amino acid precursor protein that contains the PBAN peptide sequence. Proteolytic processing of this protein, which has structural features consistent with its being a preprohormone, is predicted to generate Hez-PBAN and four additional neuropeptides having a common C-terminal pentapeptide motif, Phe-Xaa-Pro-(Arg or Lys)-Leu (Xaa = Gly, Ser, or Thr), which is also found in insect pyrokinin and myotropin peptide families"
Keywords:		"Amino Acid Sequence Animals Base Sequence Blotting, Northern Bombyx/genetics/metabolism DNA/genetics DNA Primers DNA, Complementary/analysis Exons Female Lepidoptera/*genetics/*metabolism Male Molecular Sequence Data Neuropeptides/*biosynthesis Polymerase;"
Notes:		"MedlineMa, P W Knipple, D C Roelofs, W L eng Comparative Study Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. 1994/07/05 Proc Natl Acad Sci U S A. 1994 Jul 5; 91(14):6506-10. doi: 10.1073/pnas.91.14.6506"