| Title: | Volatile organic compounds in head and neck squamous cell carcinoma-An in vitro pilot study |
| Author(s): | Kulas P; Seidel M; Bozzato A; Schick B; Sessler DI; Kreuer S; Huppe T; |
| Address: | "Department of Otorhinolaryngology, Head and Neck Surgery, Saarland University Medical Center, Homburg (Saar), Germany. Center of Breath Research, Department of Anesthesiology, Intensive Care and Pain Therapy, Saarland University Medical Center, Homburg (Saar), Germany. Department of Outcomes Research, Anesthesiology Institute, Cleveland Clinic, Cleveland, Ohio, USA" |
| ISSN/ISBN: | 1099-0801 (Electronic) 0269-3879 (Linking) |
| Abstract: | "Owing to the lack of specific symptoms, diagnosis of head and neck squamous cell carcinoma (HNSCC) may be delayed. We evaluated volatile organic compounds in tumor samples from patients suffering from HNSCC and tested the hypothesis that there is a characteristic altered composition in the headspace of HNSCC compared with control samples from the same patient with normal squamous epithelium. These results provide the basis for future noninvasive breath analysis in HNSCC. Headspace air of suspected tumor and contralateral control samples in 20 patients were analyzed using ion-mobility spectrometry. Squamous cell carcinoma was diagnosed in 16 patients. In total, we observed 93 different signals in headspace measurements. Squamous cell carcinomas revealed significantly higher levels of volatile cyclohexanol (0.54 ppb(v) , 25th to 75th percentiles 0.35-0.86) compared with healthy squamous epithelium (0.24 ppb(v) , 25th to 75th percentiles 0.12-0.3; p < 0.001). In conclusion, head and neck squamous cell carcinoma emitted significantly higher levels of volatile cyclohexanol in headspace compared with normal squamous epithelium. These findings form the basis for future breath analysis for diagnosis, therapy control and the follow-up of HNSSC to improve therapy and aftercare" |
| Keywords: | "Aged Aged, 80 and over Breath Tests Female Humans Male Middle Aged Pilot Projects Squamous Cell Carcinoma of Head and Neck/chemistry/*diagnosis/metabolism Volatile Organic Compounds/*chemistry/metabolism head and neck squamous cell carcinoma headspace mea;" |
| Notes: | "MedlineKulas, Philipp Seidel, Martin Bozzato, Alessandro Schick, Bernhard Sessler, Daniel I Kreuer, Sascha Huppe, Tobias eng England 2020/02/15 Biomed Chromatogr. 2020 May; 34(5):e4811. doi: 10.1002/bmc.4811. Epub 2020 Feb 24" |
