| Title: | Urinary benzene metabolite and insulin resistance in elderly adults |
| Author(s): | Choi YH; Kim JH; Lee BE; Hong YC; |
| Address: | "Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea; Institute of Environmental Medicine, Seoul National University Medical Research Center, Seoul, Republic of Korea. Institute of Environmental Medicine, Seoul National University Medical Research Center, Seoul, Republic of Korea; Environmental Health Center, Seoul National University Medical Research Center, Seoul, Republic of Korea. Environmental Health Research Division, National Institute of Environmental Research, Incheon, Republic of Korea. Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea; Institute of Environmental Medicine, Seoul National University Medical Research Center, Seoul, Republic of Korea; Environmental Health Center, Seoul National University Medical Research Center, Seoul, Republic of Korea. Electronic address: ychong1@snu.ac.kr" |
| DOI: | 10.1016/j.scitotenv.2014.02.121 |
| ISSN/ISBN: | 1879-1026 (Electronic) 0048-9697 (Linking) |
| Abstract: | "BACKGROUND: Benzene is a volatile organic compound present in traffic-related and indoor air pollution. It is of particular concern since it is known to induce oxidative stress, which can affect insulin resistance (IR). We therefore examined the association between exposure to environmental benzene and IR in the elderly. STUDY DESIGN: Between 2008 and 2010, benzene metabolite levels (urinary trans,trans-muconic acid (t,t-MA)) and homeostatic model assessment index (HOMA-IR) were repeatedly measured in 505 adults aged >/=60 years. Linear mixed-effect models and marginal logistic models were used to evaluate associations of t,t-MA concentration with HOMA-IR score and elevated IR, defined as HOMA-IR >/=2.6. RESULTS: After adjustment for sociodemographic and behavioral factors, environmental co-exposures, and metabolic conditions, quartile levels of urinary t,t-MA demonstrated a dose-dependent association with elevated IR (p-trend<0.001) and the level of oxidative stress estimated by urinary malondialdehyde (p-trend<0.001). As compared to the lowest quartile, the upper quartiles of t,t-MA (t,t-MA concentration >0.017mg/g CR) were associated with elevated IR [odds ratio=Q2: 2.00 (95% confidence interval (CI): 1.16-3.46); Q3: 3.33 (95% CI: 1.90-5.84); Q4: 2.07 (95% CI: 1.02-4.22)]. CONCLUSION: Urinary benzene at levels currently observed in the urban elderly population is associated with IR, independent of traditional risk factors. Reduction of community-level exposure to benzene is therefore important for the effective prevention of IR in older adults" |
| Keywords: | "Aged Aged, 80 and over Air Pollutants/*urine Air Pollution, Indoor/analysis/statistics & numerical data Benzene/*metabolism Biomarkers/urine Environmental Exposure/*analysis/statistics & numerical data Female Humans *Insulin Resistance Male Malondialdehyd;" |
| Notes: | "MedlineChoi, Yoon-Hyeong Kim, Jin Hee Lee, Bo-Eun Hong, Yun-Chul eng Research Support, Non-U.S. Gov't Netherlands 2014/03/25 Sci Total Environ. 2014 Jun 1; 482-483:260-8. doi: 10.1016/j.scitotenv.2014.02.121. Epub 2014 Mar 20" |
