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Cell Rep

Title:		Representation of Olfactory Information in Organized Active Neural Ensembles in the Hypothalamus
Author(s):		Carvalho VMA; Nakahara TS; Souza MAA; Cardozo LM; Trintinalia GZ; Pissinato LG; Venancio JO; Stowers L; Papes F;
Address:		"Department of Genetics, Evolution, Microbiology and Immunology, Institute of Biology, University of Campinas, Rua Monteiro Lobato, 255, Campinas, Sao Paulo 13083-862, Brazil; Graduate Program in Genetics and Molecular Biology, Institute of Biology, University of Campinas, Rua Monteiro Lobato, 255, Campinas, Sao Paulo 13083-862, Brazil; Department of Cell Biology, Scripps Research, 10550 N. Torrey Pines Rd., La Jolla, CA 92037, USA. Department of Genetics, Evolution, Microbiology and Immunology, Institute of Biology, University of Campinas, Rua Monteiro Lobato, 255, Campinas, Sao Paulo 13083-862, Brazil; Graduate Program in Genetics and Molecular Biology, Institute of Biology, University of Campinas, Rua Monteiro Lobato, 255, Campinas, Sao Paulo 13083-862, Brazil. Department of Genetics, Evolution, Microbiology and Immunology, Institute of Biology, University of Campinas, Rua Monteiro Lobato, 255, Campinas, Sao Paulo 13083-862, Brazil. Department of Cell Biology, Scripps Research, 10550 N. Torrey Pines Rd., La Jolla, CA 92037, USA. Department of Genetics, Evolution, Microbiology and Immunology, Institute of Biology, University of Campinas, Rua Monteiro Lobato, 255, Campinas, Sao Paulo 13083-862, Brazil. Electronic address: papesf@unicamp.br"
Journal Title:		Cell Rep
Year:		2020
Volume:		32
Issue:		8
Page Number:		108061 -
DOI:		10.1016/j.celrep.2020.108061
ISSN/ISBN:		2211-1247 (Electronic)
Abstract:		"The internal representation of sensory information via coherent activation of specific pathways in the nervous system is key to appropriate behavioral responses. Little is known about how chemical stimuli that elicit instinctive behaviors lead to organized patterns of activity in the hypothalamus. Here, we study how a wide range of chemosignals form a discernible map of olfactory information in the ventromedial nucleus of the hypothalamus (VMH) and show that different stimuli entail distinct active neural ensembles. Importantly, we demonstrate that this map depends on functional inputs from the vomeronasal organ. We present evidence that the spatial locations of active VMH ensembles are correlated with activation of distinct vomeronasal receptors and that disjunct VMH ensembles exhibit differential projection patterns. Moreover, active ensembles with distinct spatial locations are not necessarily associated with different behavior categories, such as defensive or social, calling for a revision of the currently accepted model of VMH organization"
Keywords:		Animals Humans Hypothalamus/*physiology Mice Olfactory Bulb/*physiology internal representation odors olfaction periaqueductal gray pheromones sensory neural map ventromedial hypothalamus vomeronasal organ vomeronasal receptors;
Notes:		"MedlineCarvalho, Vinicius Miessler de Andrade Nakahara, Thiago Seike Souza, Mateus Augusto de Andrade Cardozo, Leonardo Minete Trintinalia, Guilherme Ziegler Pissinato, Leonardo Granato Venancio, Jose Otavio Stowers, Lisa Papes, Fabio eng Research Support, Non-U.S. Gov't 2020/08/28 Cell Rep. 2020 Aug 25; 32(8):108061. doi: 10.1016/j.celrep.2020.108061"