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Cell

Title:		"Yeast peptide pheromones, a-factor and alpha-factor, activate a common response mechanism in their target cells"
Author(s):		Bender A; Sprague GF;
Address:
Journal Title:		Cell
Year:		1986
Volume:		47
Issue:		6
Page Number:		929 - 937
DOI:		10.1016/0092-8674(86)90808-1
ISSN/ISBN:		0092-8674 (Print) 0092-8674 (Linking)
Abstract:		"We show that in yeast the cell type specificity of pheromone response is determined solely by the species of receptor that a cell synthesizes. The two receptor-pheromone interactions are functionally interchangeable and involve the creation of a common intracellular signal. In particular, we find that provision of a-factor receptor or alpha-factor receptor in mat alpha 1 mutants, which normally do not express either receptor or any other a- or alpha-specific products, allows response to the appropriate pheromone. Moreover, provision of a-factor receptor in a cells lacking alpha-factor receptor restores mating competence to those cells. Finally, an aspect of pheromone response that is normally unique to a-factor action on alpha cells--increased transcription from the alpha-specific STE3 gene--can also be observed following alpha-factor treatment of pseudo-a cells (mat alpha 2 ste3 ste13), special mutants that respond to alpha-factor and also have an active STE3 promoter"
Keywords:		"Genes, Fungal Interphase Mating Factor Peptides/*metabolism/pharmacology Pheromones/*metabolism Receptors, Cell Surface/genetics/*metabolism Receptors, Mating Factor *Receptors, Peptide Saccharomyces cerevisiae/genetics/*metabolism/physiology *Transcripti;"
Notes:		"MedlineBender, A Sprague, G F Jr eng GM00715/GM/NIGMS NIH HHS/ GM30027/GM/NIGMS NIH HHS/ Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. 1986/12/26 Cell. 1986 Dec 26; 47(6):929-37. doi: 10.1016/0092-8674(86)90808-1"