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Dev Cell

Title:		The TIKI/TraB/PrgY family: a common protease fold for cell signaling from bacteria to metazoa?
Author(s):		Bazan JF; Macdonald BT; He X;
Address:		"4(th) and Aspen Life Sciences, Stillwater, MN 55082, USA. jfbazan@4thandaspen.com"
Journal Title:		Dev Cell
Year:		2013
Volume:		25
Issue:		3
Page Number:		225 - 227
DOI:		10.1016/j.devcel.2013.04.019
ISSN/ISBN:		1878-1551 (Electronic) 1534-5807 (Print) 1534-5807 (Linking)
Abstract:		"We report that the metazoan Wnt protease and signaling inhibitor TIKI shares sequence homology with bacterial TraB/PrgY proteins, inhibitors of pheromone signaling essential for propagation of antibiotic resistance. Our analysis suggests that these proteins represent an ancient metalloprotease clan regulating cellular communications across biological kingdoms"
Keywords:		"Animals Bacteria/*enzymology Bacterial Proteins/*metabolism Catalytic Domain Cell Communication Drug Resistance, Bacterial/genetics Metalloproteases/*metabolism Pheromones/antagonists & inhibitors *Protein Folding Protein Structure, Secondary Protein Stru;"
Notes:		"MedlineBazan, J Fernando Macdonald, Bryan T He, Xi eng P30 HD-18655/HD/NICHD NIH HHS/ R01 GM057603/GM/NIGMS NIH HHS/ GM057603S1/GM/NIGMS NIH HHS/ P30 HD018655/HD/NICHD NIH HHS/ R01 AR060359/AR/NIAMS NIH HHS/ Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't 2013/05/16 Dev Cell. 2013 May 13; 25(3):225-7. doi: 10.1016/j.devcel.2013.04.019"