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Anal Chem

Title:		Evaluation of a New DC-Ion Funnel Drift Tube for Use in Proton Transfer Reaction Mass Spectrometry
Author(s):		Zhang Q; Bao X; Liang Q; Sun Q; Xu W; Zou X; Huang C; Shen C; Chu Y;
Address:		"Anhui Province Key Laboratory of Medical Physics and Technology, Institute of Health and Medical Technology, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei 230031, P. R. China. University of Science and Technology of China, Hefei 230026, China. Hefei Cancer Hospital, Chinese Academy of Sciences, Hefei 230031, P. R. China"
Journal Title:		Anal Chem
Year:		2022
Volume:		20220510
Issue:		20
Page Number:		7174 - 7180
DOI:		10.1021/acs.analchem.1c05086
ISSN/ISBN:		1520-6882 (Electronic) 0003-2700 (Linking)
Abstract:		"We have developed and characterized a novel drift tube called the direct current-ion funnel (DC-ion funnel) drift tube, consisting of 20 traditional ring electrodes and 5 new DC-focusing electrodes (DC-FEs) for use in proton transfer reaction mass spectrometry (PTR-MS). Ion trajectory simulations demonstrate the ion focusing effect of the DC-FE and DC-ion funnel drift tube. Further comparative experiments show that the PTR-MS with the novel DC-ion funnel drift tube has a higher sensitivity (3.8-7.3 times for the volatile organic compounds considered in this work) than the PTR-MS with a traditional drift tube. Different from conventional radiofrequency (rf) focusing methods, the DC-ion funnel drift tube can realize ion focusing with only a DC electric field and no additional rf power supply, which makes it especially suitable for instruments requiring miniaturization and low power consumption to improve detection sensitivity. In addition, the DC-ion funnel drift tube can easily be coupled to other types of mass spectrometers to increase their detection sensitivity"
Keywords:		Electricity Electrodes Mass Spectrometry/methods *Protons *Volatile Organic Compounds/analysis;
Notes:		"MedlineZhang, Qiangling Bao, Xun Liang, Qu Sun, Qin Xu, Wei Zou, Xue Huang, Chaoqun Shen, Chengyin Chu, Yannan eng Research Support, Non-U.S. Gov't 2022/05/11 Anal Chem. 2022 May 24; 94(20):7174-7180. doi: 10.1021/acs.analchem.1c05086. Epub 2022 May 10"