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Med Klin Intensivmed Notfmed

Title:		[Modern breath analysis]
Author(s):		Wirtz LM; Kreuer S; Volk T; Huppe T;
Address:		"Center of Breath Research (CBR); Klinik fur Anasthesiologie, Intensivmedizin und Schmerztherapie, Universitatsklinikum des Saarlandes, Kirrberger Strasse 100, Gebaude 57, 66424, Homburg (Saar), Deutschland. lukas.wirtz@uks.eu. Center of Breath Research (CBR); Klinik fur Anasthesiologie, Intensivmedizin und Schmerztherapie, Universitatsklinikum des Saarlandes, Kirrberger Strasse 100, Gebaude 57, 66424, Homburg (Saar), Deutschland"
Journal Title:		Med Klin Intensivmed Notfmed
Year:		2019
Volume:		20190206
Issue:		7
Page Number:		655 - 660
DOI:		10.1007/s00063-019-0544-0
ISSN/ISBN:		2193-6226 (Electronic) 2193-6218 (Linking)
Abstract:		"BACKGROUND: Analysis of exhaled air is a risk-free option for bedside diagnostics. Modern breath analysis can detect very low concentrations of volatile components. Current research focuses on drug monitoring and diagnosis of various diseases. OBJECTIVES: Presentation and discussion of current breath research relevant to intensive care medicine. MATERIALS AND METHODS: The literature in PubMed was searched using the following terms: 'breath analysis', 'volatile organic compounds', 'critically ill' combined with 'drug monitoring', 'propofol', 'heart failure', 'pneumonia', 'ARDS', 'renal failure', 'liver failure', 'sepsis' or 'hemorrhage'. RESULTS: Intravenously administered propofol can now be measured reliably in exhaled air. Functional impairments of the heart, lungs, kidneys and liver show characteristic influences on the exhaled air, which could serve as a new diagnostic tool in the future. Animal experiments already show promising results to detect sepsis, hemorrhage and ventilator-induced lung injury. CONCLUSIONS: In the future, modern breath analysis could enable non-invasive drug monitoring and diagnostics of medical conditions relevant to intensive care medicine"
Keywords:		*Breath Tests/methods Exhalation/physiology Humans *Volatile Organic Compounds/analysis Breath analysis Drug monitoring Exhaled air analysis Intensive care Volatile biomarkers;
Notes:		"MedlineWirtz, L M Kreuer, S Volk, T Huppe, T ger Review Germany 2019/02/07 Med Klin Intensivmed Notfmed. 2019 Oct; 114(7):655-660. doi: 10.1007/s00063-019-0544-0. Epub 2019 Feb 6"