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J Lipid Res

Title:		Flexible origin of hydrocarbon/pheromone precursors in Drosophila melanogaster
Author(s):		Wicker-Thomas C; Garrido D; Bontonou G; Napal L; Mazuras N; Denis B; Rubin T; Parvy JP; Montagne J;
Address:		"Laboratoire Evolution, Genomes, Comportement et Ecologie, CNRS Universite Paris-Sud, UMR 9191, F-91190, Gif-sur-Yvette, France. Institut for Integrative Biology of the Cell (I2BC), CNRS, Universite Paris-Sud, CEA, UMR 9198, F-91190, Gif-sur-Yvette, France. Institut for Integrative Biology of the Cell (I2BC), CNRS, Universite Paris-Sud, CEA, UMR 9198, F-91190, Gif-sur-Yvette, France Sorbonne Universites, UPMC Univ Paris 06, UFR 927, F-75005, Paris, France"
Journal Title:		J Lipid Res
Year:		2015
Volume:		20150909
Issue:		11
Page Number:		2094 - 2101
DOI:		10.1194/jlr.M060368
ISSN/ISBN:		1539-7262 (Electronic) 0022-2275 (Print) 0022-2275 (Linking)
Abstract:		"In terrestrial insects, cuticular hydrocarbons (CHCs) provide protection from desiccation. Specific CHCs can also act as pheromones, which are important for successful mating. Oenocytes are abdominal cells thought to act as specialized units for CHC biogenesis that consists of long-chain fatty acid (LCFA) synthesis, optional desaturation(s), elongation to very long-chain fatty acids (VLCFAs), and removal of the carboxyl group. By investigating CHC biogenesis in Drosophila melanogaster, we showed that VLCFA synthesis takes place only within the oenocytes. Conversely, several pathways, which may compensate for one another, can feed the oenocyte pool of LCFAs, suggesting that this step is a critical node for regulating CHC synthesis. Importantly, flies deficient in LCFA synthesis sacrificed their triacylglycerol stores while maintaining some CHC production. Moreover, pheromone production was lower in adult flies that emerged from larvae that were fed excess dietary lipids, and their mating success was lower. Further, we showed that pheromone production in the oenocytes depends on lipid metabolism in the fat tissue and that fatty acid transport protein, a bipartite acyl-CoA synthase (ACS)/FA transporter, likely acts through its ACS domain in the oenocyte pathway of CHC biogenesis. Our study highlights the importance of environmental and physiological inputs in regulating LCFA synthesis to eventually control sexual communication in a polyphagous animal"
Keywords:		"Animals Biosynthetic Pathways Drosophila Proteins/metabolism Drosophila melanogaster/*metabolism Fat Body/metabolism Fatty Acid Synthase, Type I/metabolism Fatty Acids/metabolism Female Homeostasis Larva/metabolism Lipid Droplets/metabolism *Lipid Metabol;"
Notes:		"MedlineWicker-Thomas, Claude Garrido, Damien Bontonou, Gwenaelle Napal, Laura Mazuras, Nicolas Denis, Beatrice Rubin, Thomas Parvy, Jean-Philippe Montagne, Jacques eng Research Support, Non-U.S. Gov't 2015/09/12 J Lipid Res. 2015 Nov; 56(11):2094-101. doi: 10.1194/jlr.M060368. Epub 2015 Sep 9"