| Title: | Bioaccessibility and bioavailability of environmental semi-volatile organic compounds via inhalation: A review of methods and models |
| Author(s): | Wei W; Bonvallot N; Gustafsson A; Raffy G; Glorennec P; Krais A; Ramalho O; Le Bot B; Mandin C; |
| Address: | "University of Paris-Est, Scientific and Technical Center for Building (CSTB), Health and Comfort Department, French Indoor Air Quality Observatory (OQAI), 84 Avenue Jean Jaures, Champs sur Marne, 77447 Marne la Vallee Cedex 2, France. Electronic address: Wenjuan.Wei@cstb.fr. EHESP-School of Public Health, Sorbonne Paris Cite, Rennes, France; INSERM-UMR 1085, Irset-Research Institute for Environmental and Occupational Health, Rennes, France. Swetox, Karolinska Institute, Unit of Toxicology Sciences, Forskargatan 20, SE-151 36 Sodertalje, Sweden; Department of Chemistry, Umea University, Linnaeus vag 6, SE-901 87 Umea, Sweden. EHESP-School of Public Health, Sorbonne Paris Cite, Rennes, France; INSERM-UMR 1085, Irset-Research Institute for Environmental and Occupational Health, Rennes, France; LERES-Environment and Health Research Laboratory (Irset and EHESP Technologic Platform), Rennes, France. Swetox, Karolinska Institute, Unit of Toxicology Sciences, Forskargatan 20, SE-151 36 Sodertalje, Sweden; Department of Occupational and Environmental Medicine, Department of Laboratory Medicine, Lund University, SE-221 85, Lund, Sweden. University of Paris-Est, Scientific and Technical Center for Building (CSTB), Health and Comfort Department, French Indoor Air Quality Observatory (OQAI), 84 Avenue Jean Jaures, Champs sur Marne, 77447 Marne la Vallee Cedex 2, France" |
| DOI: | 10.1016/j.envint.2018.01.024 |
| ISSN/ISBN: | 1873-6750 (Electronic) 0160-4120 (Linking) |
| Abstract: | "Semi-volatile organic compounds (SVOCs) present in indoor environments are known to cause adverse health effects through multiple routes of exposure. To assess the aggregate exposure, the bioaccessibility and bioavailability of SVOCs need to be determined. In this review, we discussed measurements of the bioaccessibility and bioavailability of SVOCs after inhalation. Published literature related to this issue is available for 2,3,7,8-tetrachlorodibenzo-p-dioxin and a few polycyclic aromatic hydrocarbons, such as benzo[a]pyrene and phenanthrene. Then, we reviewed common modeling approaches for the characterization of the gas- and particle-phase partitioning of SVOCs during inhalation. The models are based on mass transfer mechanisms as well as the structure of the respiratory system, using common computational techniques, such as computational fluid dynamics. However, the existing models are restricted to special conditions and cannot predict SVOC bioaccessibility and bioavailability in the whole respiratory system. The present review notes two main challenges for the estimation of SVOC bioaccessibility and bioavailability via inhalation in humans. First, in vitro and in vivo methods need to be developed and validated for a wide range of SVOCs. The in vitro methods should be validated with in vivo tests to evaluate human exposures to SVOCs in airborne particles. Second, modeling approaches for SVOCs need to consider the whole respiratory system. Alterations of the respiratory cycle period and human biological variability may be considered in future studies" |
| Keywords: | "Air Pollutants/*pharmacokinetics Air Pollution, Indoor Animals Biological Availability Humans *Inhalation Exposure Models, Biological Polychlorinated Dibenzodioxins/pharmacokinetics Polycyclic Aromatic Hydrocarbons/*pharmacokinetics Respiratory System/che;" |
| Notes: | "MedlineWei, Wenjuan Bonvallot, Nathalie Gustafsson, Asa Raffy, Gaelle Glorennec, Philippe Krais, Annette Ramalho, Olivier Le Bot, Barbara Mandin, Corinne eng Research Support, Non-U.S. Gov't Review Netherlands 2018/02/16 Environ Int. 2018 Apr; 113:202-213. doi: 10.1016/j.envint.2018.01.024. Epub 2018 Feb 13" |
