| Title: | Control of solvent use in medical devices by proton transfer reaction mass spectrometry and ion molecule reaction mass spectrometry |
| Author(s): | Wang Y; Han H; Shen C; Li J; Wang H; Chu Y; |
| Address: | "Laboratory of Environmental Spectroscopy, Anhui Institute of Optics and Fine Mechanics, Chinese Academy of Sciences, P.O. Box 1125, Hefei, 230031 Anhui, PR China" |
| DOI: | 10.1016/j.jpba.2009.04.020 |
| ISSN/ISBN: | 1873-264X (Electronic) 0731-7085 (Linking) |
| Abstract: | "A homemade proton transfer reaction mass spectrometer (PTR-MS) and a commercial ion molecule reaction mass spectrometer (IMR-MS) have been applied to detect volatile organic compounds (VOCs) in the packaging bags of infusion sets made of polyvinylchloride (PVC) plastic. The most abundant characteristic ions in the PTR-MS and IMR-MS measurements are observed at m/z 99 and 98 respectively, which are the results of soft ionizations that a residual chemical undergoes the proton transfer reaction in PTR-MS and the charge transfer reaction in IMR-MS. On the basis of ionic intensity dependence on the reduced-field in the PTR-MS investigation, the residue can be unambiguously identified as cyclohexanone, a commonly used adhesive agent in PVC medical device manufacture. Quantitative measurement by PTR-MS shows that concentrations of cyclohexanone in the packages of two types of infusion sets are 11 and 20 ppm respectively. Due to fast response, absolute concentration detection, and high sensitivity, the PTR-MS and IMR-MS detection methods are proposed for the quality control of medical devices including the detection of illegal or excessive uses of chemical solvents like cyclohexanone" |
| Keywords: | Cyclohexanones *Equipment and Supplies Mass Spectrometry/*methods *Solvents; |
| Notes: | "MedlineWang, Yujie Han, Haiyan Shen, Chengyin Li, Jianquan Wang, Hongmei Chu, Yannan eng Research Support, Non-U.S. Gov't England 2009/05/27 J Pharm Biomed Anal. 2009 Sep 8; 50(2):252-6. doi: 10.1016/j.jpba.2009.04.020. Epub 2009 May 3" |
