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Environ Res

Title:		Influence of maternal and sociodemographic characteristics on the accumulation of organohalogen compounds in Argentinian women. The EMASAR study
Author(s):		Bravo N; Hansen S; Okland I; Gari M; Alvarez MV; Matiocevich S; Odland JO; Grimalt JO;
Address:		"Institute of Environmental Assessment and Water Research (IDAEA-CSIC), Department of Environmental Chemistry, Jordi Girona, 18, 08034 Barcelona, Catalonia, Spain. UiT The Arctic University of Norway, Hansine Hansens veg, 18, 9019 Tromso, Norway. Department of Obstetrics and Gynecology, Stavanger University Hospital, P.O. Box 8100, N-4068 Stavanger, Norway. Hospital Publico Materno Infantil de Salta, Sarmiento, 1301, 4400 Salta, Argentina. Clinica San Jorge, Onachanga, 184, 9410 Ushuaia, Tierra del Fuego, Argentina. Institute of Environmental Assessment and Water Research (IDAEA-CSIC), Department of Environmental Chemistry, Jordi Girona, 18, 08034 Barcelona, Catalonia, Spain. Electronic address: joan.grimalt@idaea.csic.es"
Journal Title:		Environ Res
Year:		2017
Volume:		20170725
Issue:
Page Number:		759 - 767
DOI:		10.1016/j.envres.2017.07.033
ISSN/ISBN:		1096-0953 (Electronic) 0013-9351 (Linking)
Abstract:		"The occurrence of organohalogen compounds in venous serum from post-partum mothers from two Argentinian cities, Salta and Ushuaia, has been investigated (n = 698). 4,4'-DDE was the most abundant compound in these cities, with geometric means of 33 and 67ng/g lipid weight, respectively. City of residence, age and parity were the main determinants of the accumulation of these compounds. Hexachlorobenzene (HCB) was the second most abundant pollutant in Ushuaia, 8.7ng/g lipid, and beta-hexachlorocyclohexane (beta-HCH) in Salta, 7.8ng/g lipid. Decabromodiphenyl ether was higher in Ushuaia than Salta, 8.2 and 4.1ng/g lipid, respectively. The predominance of beta-HCH, 4,4'-DDE and 4,4'-DDT in Salta was related with higher use of pesticides for agricultural applications. The observed higher concentrations of 4,4'-DDE and 4,4'-DDT in the mothers from rural+semi-urban sites than in urban areas were consistent with this agricultural origin. In addition, the most volatile organochlorine compounds included in this study, HCB and alpha-HCH, were mainly found in Ushuaia. The concentrations of the studied organohalogen pollutants in Argentina were lower than those found in other similar studies which is consistent with the location of these cities in the southern hemisphere. Age, mainly for 4,4'-DDE and polychlorobiphenyl (PCB) congeners 138, 153 and 180, and parity, mainly for HCB, beta-HCH, 4,4'-DDT and PCB congener 118, were the second main determinants of the concentrations of these compounds. Gestational weight gain also influenced on the maternal levels of HCB, beta-HCH, 4,4'-DDT and PCB congeners 118, 138 and 153. Higher weight accumulation during pregnancy involved dilution of these persistent pollutants. Body mass index (BMI) was a statistically significant determinant for 4,4'-DDT, alpha-HCH and PCB congeners 153 and 180. The observed direct correspondence between higher BMI and 4,4'-DDT concentrations was in agreement with the above reported inputs related with agricultural applications. The reverse correspondence of BMI with alpha-HCH and the PCB congeners indicated higher dilution at higher weight increase"
Keywords:		"Adolescent Adult Age Factors Argentina Body Burden Body Mass Index Environmental Pollutants/*blood Female Geography Humans Hydrocarbons, Halogenated/*blood Middle Aged Mothers Parity Polychlorinated Biphenyls/*blood Weight Gain Young Adult Age dependence;"
Notes:		"MedlineBravo, Natalia Hansen, Solrunn Okland, Inger Gari, Merce Alvarez, Marisa V Matiocevich, Silvina Odland, Jon-Oyvind Grimalt, Joan O eng Research Support, Non-U.S. Gov't Netherlands 2017/07/29 Environ Res. 2017 Oct; 158:759-767. doi: 10.1016/j.envres.2017.07.033. Epub 2017 Jul 25"