| Title: | Low concentrations of the benzodiazepine drug oxazepam induce anxiolytic effects in wild-caught but not in laboratory zebrafish |
| Author(s): | Vossen LE; Cerveny D; Sen Sarma O; Thornqvist PO; Jutfelt F; Fick J; Brodin T; Winberg S; |
| Address: | "Department of Neuroscience, Uppsala University, Uppsala, Sweden. Electronic address: laura.vossen@neuro.uu.se. Swedish University of Agricultural Sciences, Department of Wildlife, Fish and Environmental Studies, Umea, Sweden; Umea University, Department of Chemistry, Umea, Sweden; University of South Bohemia in Ceske Budejovice, Faculty of Fisheries and Protection of Waters, South Bohemian Research Center of Aquaculture and Biodiversity of Hydrocenoses, Zatisi 728/II, 389 25 Vodnany, Czech Republic. Department of Neuroscience, Uppsala University, Uppsala, Sweden. Norwegian University of Science and Technology, Department of Biology, Trondheim, Norway. University of South Bohemia in Ceske Budejovice, Faculty of Fisheries and Protection of Waters, South Bohemian Research Center of Aquaculture and Biodiversity of Hydrocenoses, Zatisi 728/II, 389 25 Vodnany, Czech Republic. Swedish University of Agricultural Sciences, Department of Wildlife, Fish and Environmental Studies, Umea, Sweden" |
| DOI: | 10.1016/j.scitotenv.2019.134701 |
| ISSN/ISBN: | 1879-1026 (Electronic) 0048-9697 (Linking) |
| Abstract: | "Pollution by psychoactive pharmaceuticals has been found to disrupt anti-predator behaviors of wild fish. The challenge is now to identify which of the many psychoactive drugs pose the greatest threat. One strategy is to screen for behavioral effects of selected pharmaceuticals using a single, widely available fish species such as zebrafish. Here, we show that although such high-throughput behavioral screening might facilitate comparisons between pharmaceuticals, the choice of strain is essential. While wild-caught zebrafish exposed to concentrations of the anxiolytic drug oxazepam as low as 0.57?ª+mug L(-1) showed a reduction in the response to conspecific alarm pheromone, laboratory strain AB did not respond to the alarm cue, and consequently, the anxiolytic effect of oxazepam could not be measured. Adaptation to the laboratory environment may have rendered laboratory strains unfit for use in some ecotoxicological and pharmacological studies, since the results might not translate to wild fish populations" |
| Keywords: | "Animals Anti-Anxiety Agents Benzodiazepines Oxazepam Water Pollutants, Chemical *Zebrafish Domestication Gaba Pharmaceutical pollution Schreckstoff;neuroscience;" |
| Notes: | "MedlineVossen, Laura E Cerveny, Daniel Sen Sarma, Oly Thornqvist, Per-Ove Jutfelt, Fredrik Fick, Jerker Brodin, Tomas Winberg, Svante eng Netherlands 2019/11/18 Sci Total Environ. 2020 Feb 10; 703:134701. doi: 10.1016/j.scitotenv.2019.134701. Epub 2019 Nov 1" |
