| Title: | Associations between select blood VOCs and hematological measures in NHANES 2005-2010 |
| Author(s): | Vaughan Watson C; Naik S; Lewin M; Ragin-Wilson A; Irvin-Barnwell E; |
| Address: | "Division of Toxicology and Human Health Sciences, Agency for Toxic Substances and Disease Registry, Centers for Disease Control and Prevention, Atlanta, GA, USA. bsu8@cdc.gov. Division of Toxicology and Human Health Sciences, Agency for Toxic Substances and Disease Registry, Centers for Disease Control and Prevention, Atlanta, GA, USA" |
| Journal Title: | J Expo Sci Environ Epidemiol |
| DOI: | 10.1038/s41370-019-0192-8 |
| ISSN/ISBN: | 1559-064X (Electronic) 1559-0631 (Print) 1559-0631 (Linking) |
| Abstract: | "Exposure to VOCs is linked to health effects ranging from asthma to cancer and to negative impacts on the hematopoietic system. We examined the association between select blood VOC concentrations and hematological measures in a representative sample of the U.S. population from NHANES cycles spanning the years 2005 to 2010. We used Cox regression to assess the association between complete blood count with five-part differential (CBC) parameters and seven select blood VOCs, while addressing low detection rates among VOCs. Tobacco smoke exposure was classified using serum cotinine levels. The not-smoke-exposed group had lower VOC levels for most analytes compared with the smoke-exposed. Correlations between benzene, toluene, ethylbenzene, and xylenes (BTEX) were moderate to strong. Statistical associations were found between benzene, toluene, ethylbenzene, xylene, and styrene (BTEXS) and hematocrit, hemoglobin, and white blood cell count among the smoke-exposed. Among the not-smoke-exposed, there was an association between BTEX and platelet count. We considered benzene most likely to be associated with higher levels of CBC concentrations. Our findings suggest VOC levels currently found in the general U.S. population are associated with changes in hematological measures, and smoking could be a contributor" |
| Keywords: | *Air Pollutants/analysis Benzene/analysis Benzene Derivatives Nutrition Surveys Toluene/analysis *Volatile Organic Compounds/analysis Xylenes Btex Hematological Hematology Smoking Voc Volatile organics; |
| Notes: | "MedlineVaughan Watson, Christina Naik, Samantha Lewin, Michael Ragin-Wilson, Angela Irvin-Barnwell, Elizabeth eng CC999999/ImCDC/Intramural CDC HHS/ 2020/01/29 J Expo Sci Environ Epidemiol. 2021 Mar; 31(2):366-376. doi: 10.1038/s41370-019-0192-8. Epub 2020 Jan 27" |
