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J Breath Res

Title:		Electronic nose in discrimination of children with uncontrolled asthma
Author(s):		Tenero L; Sandri M; Piazza M; Paiola G; Zaffanello M; Piacentini G;
Address:		"Department of Surgery, Dentistry, Paediatrics and Gynaecology, University of Verona, Verona, Italy"
Journal Title:		J Breath Res
Year:		2020
Volume:		20200721
Issue:		4
Page Number:		46003 -
DOI:		10.1088/1752-7163/ab9ab0
ISSN/ISBN:		1752-7163 (Electronic) 1752-7155 (Linking)
Abstract:		"Measuring biomarkers (e.g. volatile organic compounds [VOCs]) in exhaled breath is an attractive approach to monitor airway inflammation in asthma and other lung diseases. Olfactive technology by electronic nose (e-Nose) has been applied to identify VOCs in exhaled breath. We compared e-Nose respiratory patterns in a pediatric cohort with asthma classificate children with different asthma control. This cross-sectional study involved 38 children: 28 with asthma and 10 healthy controls . The asthmatic patients were categorized as having controlled (AC), partially controlled (APC) or uncontrolled asthma (ANC) based on level of asthma symptom control according to Global Initiative for Asthma (GINA). Clinical exams, exhaled breath collection for generating e-Nose VOC profiles, and spirometry were performed. Exhaled breath samples were obtained using a commercial electronic nose (Cyranose 320; Smith Detections, Pasadena, CA, USA). The discriminative ability of breathprints were investigated by principal component analysis and penalized logistic regression. The e-Nose was able to discriminate between the CON (controls) + AC and the ANC + APC group with an area under the curve [AUC] of 0.85 (95% confidence interval [CI] 0.72 to 0.98) and a cross-validated AUC of 0.80 (95% CI 0.70 to 0.85). Sensitivity and specificity calculated using the Youden index were 0.79 and 0.84, respectively. Exhaled biomarker patterns were easy to obtain with the device and were able to differentiate children with uncontrolled symptomatic asthma from asymptomatic controls"
Keywords:		Area Under Curve Asthma/*diagnosis/physiopathology Biomarkers/analysis Breath Tests/instrumentation Case-Control Studies Child *Electronic Nose Female Forced Expiratory Volume Humans Male Principal Component Analysis Volatile Organic Compounds/analysis;
Notes:		"MedlineTenero, Laura Sandri, Marco Piazza, Michele Paiola, Giulia Zaffanello, Marco Piacentini, Giorgio eng England 2020/06/09 J Breath Res. 2020 Jul 21; 14(4):046003. doi: 10.1088/1752-7163/ab9ab0"