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Nat Aging

Title:		Males induce premature demise of the opposite sex by multifaceted strategies
Author(s):		Booth LN; Shi C; Tantilert C; Yeo RW; Miklas JW; Hebestreit K; Hollenhorst CN; Maures TJ; Buckley MT; Murphy CT; Brunet A;
Address:		"Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA. Calico Life Sciences, South San Francisco, CA, USA. Department of Molecular Biology, Princeton University, Princeton, NJ, USA. LSI Genomics, Princeton University, Princeton, NJ, USA. Department of Molecular Biology, Princeton University, Princeton, NJ, USA. ctmurphy@princeton.edu. LSI Genomics, Princeton University, Princeton, NJ, USA. ctmurphy@princeton.edu. Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA. abrunet1@stanford.edu. Glenn Laboratories for the Biology of Aging and Stanford University, Stanford, CA, USA. abrunet1@stanford.edu"
Journal Title:		Nat Aging
Year:		2022
Volume:		20220916
Issue:		9
Page Number:		809 - 823
DOI:		10.1038/s43587-022-00276-y
ISSN/ISBN:		2662-8465 (Electronic) 2662-8465 (Linking)
Abstract:		"Interactions between the sexes negatively impact health in many species. In Caenorhabditis, males shorten the lifespan of the opposite sex-hermaphrodites or females. Here we use transcriptomic profiling and targeted screens to systematically uncover conserved genes involved in male-induced demise in C. elegans. Some genes (for example, delm-2, acbp-3), when knocked down, are specifically protective against male-induced demise. Others (for example, sri-40), when knocked down, extend lifespan with and without males, suggesting general mechanisms of protection. In contrast, many classical long-lived mutants are impacted more negatively than wild type by the presence of males, highlighting the importance of sexual environment for longevity. Interestingly, genes induced by males are triggered by specific male components (seminal fluid, sperm and pheromone), and manipulating these genes in combination in hermaphrodites induces stronger protection. One of these genes, the conserved ion channel delm-2, acts in the nervous system and intestine to regulate lipid metabolism. Our analysis reveals striking differences in longevity in single sex versus mixed sex environments and uncovers elaborate strategies elicited by sexual interactions that could extend to other species"
Keywords:		Animals Female Male Caenorhabditis elegans/genetics Semen Longevity/genetics *Caenorhabditis Spermatozoa *Disorders of Sex Development/genetics;
Notes:		"MedlineBooth, Lauren N Shi, Cheng Tantilert, Cindy Yeo, Robin W Miklas, Jason W Hebestreit, Katja Hollenhorst, Cecilia N Maures, Travis J Buckley, Matthew T Murphy, Coleen T Brunet, Anne eng K99 AG051738/AG/NIA NIH HHS/ Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't 2023/04/29 Nat Aging. 2022 Sep; 2(9):809-823. doi: 10.1038/s43587-022-00276-y. Epub 2022 Sep 16"