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J Chem Neuroanat

Title:		Localization of sex hormone binding globulin in the rat vomeronasal organ
Author(s):		Ploss VM; Gebhart VM; Gisder D; Dolz W; Jirikowski GF;
Address:		"Department of Anatomy II, University Hospital Jena, Friedrich Schiller University Jena, Germany. Department of Anatomy II, University Hospital Jena, Friedrich Schiller University Jena, Germany. Electronic address: Gustav.Jirikowski@med.uni-jena.de"
Journal Title:		J Chem Neuroanat
Year:		2014
Volume:		20140819
Issue:
Page Number:		120 - 123
DOI:		10.1016/j.jchemneu.2014.08.004
ISSN/ISBN:		1873-6300 (Electronic) 0891-0618 (Linking)
Abstract:		"Volatile and non-volatile derivates of gonadal steroids are known to act as pheromones in many mammalian species. Pheromones have multiple effects on the brain via the olfactory system. Their primary port of entry seems to be the vomeronasal organ (VNO) but the underlying cellular and molecular mechanisms are unclear so far. Recently we localized sex hormone binding globulin (SHBG) in both the main and the accessory olfactory system of rat with immunocytochemistry and RT-PCR. The accessory olfactory system consisting of VNO and accessory olfactory bulb showed high expression of SHBG. In the present paper we studied SHBG expression in the VNO in greater detail. In semithin sections we found SHBG immunostaining in the perinuclear cytoplasm of some of the sensory neurons, in sensory cilia and in their axons. A portion of the basal cells and some of the goblet cells in the non-sensory epithelium showed intense SHBG staining. SHBG was abundant in exocrine cells of the vomeronasal glands, perhaps compartimentalized in secretory vesicles. In situ hybridization revealed specific signals in sensory and non-sensory cells of the VNO. Our findings indicate that SHBG expressed in the VNO may be liberated into nasal secretions to bind aerosolic steroids. SHBG in sensory cells may be involved in signaling actions of pheromones"
Keywords:		"Animals Female Immunohistochemistry In Situ Hybridization Male Rats Rats, Wistar Sex Hormone-Binding Globulin/analysis/*biosynthesis Vomeronasal Organ/cytology/*metabolism Goblet cells Olfactory glands Olfactory sensory cells Steroid binding protein Vomer;"
Notes:		"MedlinePloss, V M Gebhart, V M Gisder, D Dolz, W Jirikowski, G F eng Netherlands 2014/08/26 J Chem Neuroanat. 2014 Nov; 61-62:120-3. doi: 10.1016/j.jchemneu.2014.08.004. Epub 2014 Aug 19"