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Cell

Title:		Epigenetic inheritance of transcriptional states in S. cerevisiae
Author(s):		Pillus L; Rine J;
Address:		"Department of Molecular and Cellular Biology, University of California, Berkeley 94720"
Journal Title:		Cell
Year:		1989
Volume:		59
Issue:		4
Page Number:		637 - 647
DOI:		10.1016/0092-8674(89)90009-3
ISSN/ISBN:		0092-8674 (Print) 0092-8674 (Linking)
Abstract:		"SIR1, one of several genes required for repression of yeast silent mating type loci, has a unique role in repression of the HML alpha locus. Single-cell assays revealed that cells with mutant alleles of SIR1, including presumptive null alleles, existed as populations of genetically identical cells whose members were in one of two different regulatory states. A minority of cells had a repressed HML alpha locus whereas the majority had a derepressed HML alpha locus. The two states were mitotically stable, although rare changes in state were observed during mitotic growth, possibly reflecting heritable changes to the HML alpha locus at or before replication. Analysis of changes in state suggests that SIR1 protein has a role in the establishment but not the maintenance of repression of silent mating type genes, whereas SIR2, SIR3, and SIR4 are required for maintenance"
Keywords:		"Alleles *Gene Expression *Genes, Fungal *Genes, Mating Type, Fungal Genotype Mating Factor Peptides/genetics Pheromones Saccharomyces cerevisiae/*genetics *Transcription, Genetic;"
Notes:		"MedlinePillus, L Rine, J eng Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. 1989/11/17 Cell. 1989 Nov 17; 59(4):637-47. doi: 10.1016/0092-8674(89)90009-3"