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Am J Gastroenterol

Title:		Fecal hydrogen sulfide production in ulcerative colitis
Author(s):		Levine J; Ellis CJ; Furne JK; Springfield J; Levitt MD;
Address:		"Department of Medicine, Minneapolis VA Medical Center and University of Minnesota Medical School, 55417, USA"
Journal Title:		Am J Gastroenterol
Year:		1998
Volume:		93
Issue:		1
Page Number:		83 - 87
DOI:		10.1111/j.1572-0241.1998.083_c.x
ISSN/ISBN:		0002-9270 (Print) 0002-9270 (Linking)
Abstract:		"OBJECTIVE: Sulfide, a product of sulfate-reducing bacteria, has been proposed to play an etiologic role in ulcerative colitis. Ulcerative colitis feces have increased numbers and activity of sulfate-reducing bacteria, but only modestly increased sulfide. However, fecal sulfide exists largely in the volatile, highly toxic H2S form that moves rapidly from feces to surrounding gas. Our aim was to quantify the fecal release of H2S and other volatiles (CO2, H2, CH4, methanethiol, and dimethylsulfide). METHODS: Fecal samples from 25 subjects with ulcerative colitis and 17 controls were incubated in 4-L containers, and gas release was assessed at intervals over 24 h. RESULTS: H2S release by ulcerative colitis feces was elevated 3-4-fold at every measurement point compared with normal feces (p < 0.003 at 24 h). The only other significant difference was increased CO2 release by ulcerative colitis feces at 1 h. Supplementation of fecal homogenates with sulfur-containing substrates showed that organic compounds (mucin, cysteine, taurocholate) provided more readily utilizable substrate for H2S production than did sulfate. CONCLUSIONS: Increased H2S release is a relatively localized metabolic aberration of ulcerative colitis feces. This increased H2S may reflect abnormalities of the fecal bacteria and/or substrate availability"
Keywords:		"Adolescent Adult Aged Aged, 80 and over Bacteria/metabolism Carbon Dioxide/analysis Carbon Monoxide/analysis Chromatography, Gas Colitis, Ulcerative/*etiology/metabolism Data Interpretation, Statistical Feces/*chemistry/microbiology Female Humans Hydrogen;"
Notes:		"MedlineLevine, J Ellis, C J Furne, J K Springfield, J Levitt, M D eng Comparative Study 1998/02/03 Am J Gastroenterol. 1998 Jan; 93(1):83-7. doi: 10.1111/j.1572-0241.1998.083_c.x"