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Biosci Biotechnol Biochem

Title:		Lifespan extending activity of substances secreted by the nematode Caenorhabditis elegans that include the dauer-inducing pheromone
Author(s):		Kawano T; Kataoka N; Abe S; Ohtani M; Honda Y; Honda S; Kimura Y;
Address:		"Department of Biological and Environmental Chemistry, Faculty of Agriculture, Tottori University, Japan. kawano@muses.tottori-u.ac.jp"
Journal Title:		Biosci Biotechnol Biochem
Year:		2005
Volume:		69
Issue:		12
Page Number:		2479 - 2481
DOI:		10.1271/bbb.69.2479
ISSN/ISBN:		0916-8451 (Print) 0916-8451 (Linking)
Abstract:		"The nematode Caenorhabditis elegans yields a substance(s) inducing the larval diapause, called dauer-inducing pheromone. We discovered that the crude pheromone extract extends the adult lifespan in the animal. This extension does not occur in the mutant animal, in which expansion of the lifespan caused by other mutations reducing insulin signaling is suppressed. This is the first description concerning the relevancy of the pheromone to the longevity in the animal"
Keywords:		Aging/drug effects/physiology Animals Antimetabolites/pharmacology Caenorhabditis elegans/drug effects/*growth & development Caenorhabditis elegans Proteins/*pharmacology Floxuridine/pharmacology Insulin/physiology Larva Longevity/*drug effects Mutation/g;
Notes:		"MedlineKawano, Tsuyoshi Kataoka, Naoya Abe, Sunao Ohtani, Mari Honda, Yoko Honda, Shuji Kimura, Yasuo eng Research Support, Non-U.S. Gov't England 2005/12/27 Biosci Biotechnol Biochem. 2005 Dec; 69(12):2479-81. doi: 10.1271/bbb.69.2479"