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Biomarkers

Title:		"Blood 2,5-dimethylfuran as a sensitive and specific biomarker for cigarette smoking"
Author(s):		Jia C; Ward KD; Mzayek F; Relyea G;
Address:		"School of Public Health, University of Memphis , Memphis, TN , USA"
Journal Title:		Biomarkers
Year:		2014
Volume:		20140701
Issue:		6
Page Number:		457 - 462
DOI:		10.3109/1354750X.2014.935956
ISSN/ISBN:		1366-5804 (Electronic) 1354-750X (Linking)
Abstract:		"OBJECTIVE: We evaluated the validity of blood 2,5-dimethylfuran (DMF) for determining smoking status using population-based data. METHODS: We obtained blood DMF concentrations and smoking status from National Health and Nutrition Examination Survey 2003-2006 and computed sensitivity, specificity and Kappa statistic. RESULTS: Self-reported smoking showed very high agreement (Kappa = 92.8-93.3%) in daily smokers and fair agreement in non-daily smokers (Kappa = 33.7-36.4%). Coffee intake did not influence the detection of blood DMF. CONCLUSIONS: Blood DMF has comparable sensitivity and specificity with serum cotinine for identifying current daily smokers, which may make it a useful biomarker in epidemiologic studies"
Keywords:		Adult Biomarkers/blood Cotinine/blood Furans/*blood Humans Middle Aged Sensitivity and Specificity Smoking/*blood Tobacco Smoke Pollution Young Adult 2 5-dimethylfuran Nhanes cotinine environmental tobacco smoke volatile organic compound;
Notes:		"MedlineJia, Chunrong Ward, Kenneth D Mzayek, Fawaz Relyea, George eng England 2014/07/02 Biomarkers. 2014 Sep; 19(6):457-62. doi: 10.3109/1354750X.2014.935956. Epub 2014 Jul 1"