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Basic Clin Pharmacol Toxicol

Title:		Monoterpenes modulating autophagy: A review study
Author(s):		Ashrafizadeh M; Ahmadi Z; Mohammadinejad R; Kaviyani N; Tavakol S;
Address:		"NanoBioEletrochemistry Research Center, Bam University of Medical Sciences, Bam, Iran. Student Research Committee, School of Medicine, Bam University of Medical Sciences, Bam, Iran. Neuroscience Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran. Pharmaceutics Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran. Department of Basic Science, Islamic Azad University, Shoushtar, Iran. Cellular and Molecular Research Center, Iran University of Medical Sciences, Tehran, Iran"
Journal Title:		Basic Clin Pharmacol Toxicol
Year:		2020
Volume:		20190719
Issue:		1
Page Number:		9 - 20
DOI:		10.1111/bcpt.13282
ISSN/ISBN:		1742-7843 (Electronic) 1742-7835 (Linking)
Abstract:		"From the beginning of the 21st century, much attention has been made towards the medicinal herbs due to their low side effects and valuable biological activities. Among them, terpenes comprise a large group of naturally occurring chemical compounds that are considered as main components of flavours, antifeedants and pheromones. Monoterpenes have demonstrated a favourable profile as compounds that have antioxidant, anti-inflammatory, anti-diabetic, hepatoprotective and anti-tumour activities. On the other hand, autophagy is a 'self-digestion' mechanism which plays a remarkable role in a number of pathological conditions such as cancer, ageing, metabolic disorders and infection. Also, autophagy is considered as a stress adaptor that may lead to apoptotic cell death under severe and sustained stress. Autophagy modulation is a promising strategy in cancer treatment, and a variety of drugs have been designed in line with this strategy. In the present MiniReview, we discuss the effects of monoterpenes on autophagy and its relationship with therapeutic impacts of monoterpenes"
Keywords:		autophagy cell stress medicinal herbs monoterpenes programmed cell death;neuroscience;
Notes:		"PubMed-not-MEDLINEAshrafizadeh, Milad Ahmadi, Zahra Mohammadinejad, Reza Kaviyani, Nasim Tavakol, Shima eng Review England 2019/06/27 Basic Clin Pharmacol Toxicol. 2020 Jan; 126(1):9-20. doi: 10.1111/bcpt.13282. Epub 2019 Jul 19"