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Proc Natl Acad Sci U S A

Title:		Modification of Streptococcus faecalis sex pheromones after acquisition of plasmid DNA
Author(s):		Ike Y; Craig RA; White BA; Yagi Y; Clewell DB;
Address:
Journal Title:		Proc Natl Acad Sci U S A
Year:		1983
Volume:		80
Issue:		17
Page Number:		5369 - 5373
DOI:		10.1073/pnas.80.17.5369
ISSN/ISBN:		0027-8424 (Print) 1091-6490 (Electronic) 0027-8424 (Linking)
Abstract:		"Recipient strains of Streptococcus faecalis excrete multiple, peptide sex pheromones that induce mating responses in donors harboring certain conjugative plasmids. Acquisition of plasmid DNA leads to a 'shutting off' of pheromone excretion, and such cells become responsive to exogenous pheromone. Data are presented showing that donors excrete low levels of a modified, inactive form of the pheromone. This substance, when mixed in excess with active pheromone, inhibits pheromone activity (probably by competition for a receptor site on the donor). Modified forms of both cPD1 and cAD1 were revealed, and each appeared to have a mass about 350-400 daltons larger than the active pheromone. In both cases, pheromone activity could be regenerated by treatment with phosphodiesterase II"
Keywords:		"Animals Chymotrypsin/pharmacology Conjugation, Genetic DNA, Bacterial/genetics Enterococcus faecalis/drug effects/*genetics Kinetics Pheromones/*genetics *Plasmids Sex Attractants/*genetics/isolation & purification Species Specificity Trypsin/pharmacology;"
Notes:		"MedlineIke, Y Craig, R A White, B A Yagi, Y Clewell, D B eng AI10318/AI/NIAID NIH HHS/ DE02731/DE/NIDCR NIH HHS/ Research Support, U.S. Gov't, P.H.S. 1983/09/01 Proc Natl Acad Sci U S A. 1983 Sep; 80(17):5369-73. doi: 10.1073/pnas.80.17.5369"