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Dermatol Surg

Title:		Making scents: improvement of olfactory profile after botulinum toxin-A treatment in healthy individuals
Author(s):		Heckmann M; Kutt S; Dittmar S; Hamm H;
Address:		"Skin Center Starnberg, Starnberg, Germany. heckmann@derma.de"
Journal Title:		Dermatol Surg
Year:		2007
Volume:		33
Issue:		1 Spec No.
Page Number:		S81 - S87
DOI:		10.1111/j.1524-4725.2006.32336.x
ISSN/ISBN:		1076-0512 (Print) 1076-0512 (Linking)
Abstract:		"BACKGROUND: The axilla is particularly associated with body odor and putative pheromone production in humans. Although botulinum toxin type A (BT-A) is injected increasingly into the axillary skin to stop excessive sweating, its potential to control body odor is largely unexplored. OBJECTIVE: The objective was to measure the impact of BT-A on human axillary odor in an objective and reproducible fashion. METHODS: This study was a randomized, double-blind, placebo-controlled trial with 51 healthy volunteers receiving 50 U of BOTOX (Allergan, Inc.) in one axilla and placebo in the other. Odor quality was assessed by treated subjects (questionnaire) as well as by independent raters who were exposed to blinded T-shirt samples. RESULTS: No major side effects occurred, and no subject withdrew from the study for medical reasons. Samples from the BT-A-treated side smelled less intense (p<.001) and better (p<.001) according to self-assessments. Likewise, independent raters found the BT-A-treated samples to smell less intense and better (p<.001). They preferred 'to work together with the respective person' and found the odor 'more erotic' (p<.001). CONCLUSION: Side-by-side comparison of odor samples (T-shirt sniff test) by independent raters showed that axillary odor in healthy individuals is significantly more appealing after BT-A injection"
Keywords:		"Adult Aged Axilla/physiology Botulinum Toxins, Type A/*pharmacology Double-Blind Method Female Humans Injections Male Middle Aged Neuromuscular Agents/*pharmacology *Odorants;"
Notes:		"MedlineHeckmann, Marc Kutt, Sandra Dittmar, Sabine Hamm, Henning eng Clinical Trial Randomized Controlled Trial Research Support, Non-U.S. Gov't 2007/01/24 Dermatol Surg. 2007 Jan; 33(1 Spec No.):S81-7. doi: 10.1111/j.1524-4725.2006.32336.x"