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Sci Rep

Title:		Multi-functional nano silver: A novel disruptive and theranostic agent for pathogenic organisms in real-time
Author(s):		Gopinath PM; Ranjani A; Dhanasekaran D; Thajuddin N; Archunan G; Akbarsha MA; Gulyas B; Padmanabhan P;
Address:		"Department of Microbiology, Bharathidasan University, Tiruchirappalli-620 024, India. National Centre for Alternatives to Animal Experiments (NCAAE), Bharathidasan University, Tiruchirappalli-620 024, India. Centre for Pheromone Technology, Department of Animal Science, School of Life Sciences, Bharathidasan University, Tiruchirappalli-620 024, India. Department of Food Science and Nutrition, College of Food and Agriculture, King Saud University, Riyadh, Kingdom of Saudi Arabia. Lee Kong Chian School of Medicine, Nanyang Technological University, 636921, Singapore"
Journal Title:		Sci Rep
Year:		2016
Volume:		20160926
Issue:
Page Number:		34058 -
DOI:		10.1038/srep34058
ISSN/ISBN:		2045-2322 (Electronic) 2045-2322 (Linking)
Abstract:		"The present study was aimed at evaluating the fluorescence property, sporicidal potency against Bacillus and Clostridium endospores, and surface disinfecting ability of biogenic nano silver. The nano silver was synthesized using an actinobacterial cell-filtrate. The fluorescence property as well as imaging facilitator potency of this nano silver was verified adopting spectrofluorometer along with fluorescent and confocal laser scanning microscope wherein strong emission and bright green fluorescence, respectively, on the entire spore surface was observed. Subsequently, the endospores of B. subtilis, B. cereus, B. amyloliquefaciens, C. perfringens and C. difficile were treated with physical sporicides, chemical sporicides and nano silver, in which the nano silver brought about pronounced inhibition even at a very low concentration. Finally, the environmental surface-sanitizing potency of nano silver was investigated adopting cage co-contamination assay, wherein vital organs of mice exposed to the nano silver-treated cage did not show any signs of pathological lesions, thus signifying the ability of nano silver to completely disinfect the spore or reduce the count required for infection. Taken these observations together, we have shown the multi-functional biological properties of the nano silver, synthesized using an actinobacterial cell-filtrate, which could be of application in advanced diagnostics, biomedical engineering and therapeutics in the near future"
Keywords:
Notes:		"PublisherGopinath, Ponnusamy Manogaran Ranjani, Anandan Dhanasekaran, Dharumadurai Thajuddin, Nooruddin Archunan, Govindaraju Akbarsha, Mohammad Abdulkader Gulyas, Balazs Padmanabhan, Parasuraman eng England 2016/09/27 Sci Rep. 2016 Sep 26; 6:34058. doi: 10.1038/srep34058"