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Clin Lab Med

Title:		Breath-Based Diagnosis of Infectious Diseases: A Review of the Current Landscape
Author(s):		Ghosh C; Leon A; Koshy S; Aloum O; Al-Jabawi Y; Ismail N; Weiss ZF; Koo S;
Address:		"Division of Infectious Diseases, Brigham and Women's Hospital, 181 Longwood Avenue, MCP642, Boston, MA 02115, USA; Harvard Medical School, 25 Shattuck Street, Boston, MA 02115, USA. Division of Infectious Diseases, Brigham and Women's Hospital, 181 Longwood Avenue, MCP642, Boston, MA 02115, USA; Harvard Medical School, 25 Shattuck Street, Boston, MA 02115, USA; Division of Infectious Diseases, Massachusetts General Hospital, Boston, MA 02114, USA. Division of Infectious Diseases, Brigham and Women's Hospital, 181 Longwood Avenue, MCP642, Boston, MA 02115, USA; Harvard Medical School, 25 Shattuck Street, Boston, MA 02115, USA; Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, MA 02215, USA. Electronic address: skoo@bwh.harvard.edu"
Journal Title:		Clin Lab Med
Year:		2021
Volume:		41
Issue:		2
Page Number:		185 - 202
DOI:		10.1016/j.cll.2021.03.002
ISSN/ISBN:		1557-9832 (Electronic) 0272-2712 (Print) 0272-2712 (Linking)
Abstract:		"Various analytical methods can be applied to concentrate, separate, and examine trace volatile organic metabolites in the breath, with the potential for noninvasive, rapid, real-time identification of various disease processes, including an array of microbial infections. Although biomarker discovery and validation in microbial infections can be technically challenging, it is an approach that has shown great promise, especially for infections that are particularly difficult to identify with standard culture and molecular amplification-based approaches. This article discusses the current state of breath analysis for the diagnosis of infectious diseases"
Keywords:		Breath Tests *Communicable Diseases/diagnosis Humans *Volatile Organic Compounds Biomarker Breath Diagnosis Metabolites Noninvasive Point-of-care Voc;
Notes:		"MedlineGhosh, Chiranjit Leon, Armando Koshy, Seena Aloum, Obadah Al-Jabawi, Yazan Ismail, Nour Weiss, Zoe Freeman Koo, Sophia eng R01 AI138999/AI/NIAID NIH HHS/ R21 AI130669/AI/NIAID NIH HHS/ R21 AI133330/AI/NIAID NIH HHS/ R21 AI156279/AI/NIAID NIH HHS/ R44 AI141264/AI/NIAID NIH HHS/ Research Support, N.I.H., Extramural Review 2021/05/23 Clin Lab Med. 2021 Jun; 41(2):185-202. doi: 10.1016/j.cll.2021.03.002"