| Title: | "Detection of urological cancers by the signature of organic volatile compounds in urine, from dogs to electronic noses" |
| Author(s): | Gaye O; Fall CB; Jalloh M; Faye B; Jobin M; Cussenot O; |
| Address: | "Urology Department, Dalal Jamm Hospital. University Cheikh Anta Diop. Urology Department, Idrissa Pouye General Hospital, Dakar, Senegal. HEPIA, University of Applied Sciences of Western Switzerland (HES-SO), Geneve, Switzerland. Nuffield Department of Surgical Sciences, University of Oxford, Oxford, UK. CeRePP, Paris, France" |
| DOI: | 10.1097/MOU.0000000000001128 |
| ISSN/ISBN: | 1473-6586 (Electronic) 0963-0643 (Linking) |
| Abstract: | "PURPOSE OF REVIEW: Urine volatile organic compound (VOC) testing for early detection of urological cancers is a minimally invasive and promising method. The objective of this review was to present the results of recently published work on this subject. RECENT FINDINGS: Organic volatile compounds are produced through oxidative stress and peroxidation of cell membranes, and they are eliminated through feces, urine, and sweat. Studies looking for VOCs in urine for the diagnosis of urological cancers have mostly focused on bladder and prostate cancers. However, the number of patients included in the studies was small. The electronic nose was the most widely used means of detecting VOCs in urine for the detection of urological cancers. MOS sensors and pattern recognition machine learning were more used for the composition of electronic noses. Early detection of urological cancers by detection of VOCs in urine is a method with encouraging results with sensitivities ranging from 27 to 100% and specificities ranging from 72 to 94%. SUMMARY: The olfactory signature of urine from patients with urological cancers is a promising biomarker for the early diagnosis of urological cancers. The electronic nose with its ability to recognize complex odors is an excellent alterative to canine diagnosis and analytical techniques. Nevertheless, additional research improving the technology of Enoses and the methodology of the studies is necessary for its implementation in daily clinical practice" |
| Keywords: | Humans Male Dogs Animals Electronic Nose Biomarkers *Urologic Neoplasms/diagnosis *Volatile Organic Compounds/urine; |
| Notes: | "MedlineGaye, Oumar Fall, Cheikh Bintou Jalloh, Mohamed Faye, Babacar Jobin, Marc Cussenot, Olivier eng Review 2023/09/08 Curr Opin Urol. 2023 Nov 1; 33(6):437-444. doi: 10.1097/MOU.0000000000001128. Epub 2023 Sep 5" |
