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J Bacteriol

Title:		Influence of the MexAB-OprM multidrug efflux system on quorum sensing in Pseudomonas aeruginosa
Author(s):		Evans K; Passador L; Srikumar R; Tsang E; Nezezon J; Poole K;
Address:		"Department of Microbiology and Immunology, Queen's University, Kingston, Ontario K7L 3N6, Canada"
Journal Title:		J Bacteriol
Year:		1998
Volume:		180
Issue:		20
Page Number:		5443 - 5447
DOI:		10.1128/JB.180.20.5443-5447.1998
ISSN/ISBN:		0021-9193 (Print) 1098-5530 (Electronic) 0021-9193 (Linking)
Abstract:		"Pseudomonas aeruginosa nalB mutants which hyperexpress the MexAB-OprM multidrug efflux system produce reduced levels of several extracellular virulence factors known to be regulated by quorum sensing. Such mutants also produce less acylated homoserine lactone autoinducer PAI-1, consistent with an observed reduction in lasI expression. These data suggest that PAI-1 is a substrate for MexAB-OprM, and its resulting exclusion from cells hyperexpressing MexAB-OprM limits PAI-1-dependent activation of lasI and the virulence genes"
Keywords:		"4-Butyrolactone/analogs & derivatives/biosynthesis Bacterial Proteins/biosynthesis/*metabolism Biological Transport Drug Resistance, Multiple/genetics Gene Expression Regulation, Bacterial Pheromones/biosynthesis Pseudomonas aeruginosa/pathogenicity/*phys;"
Notes:		"MedlineEvans, K Passador, L Srikumar, R Tsang, E Nezezon, J Poole, K eng Research Support, Non-U.S. Gov't 1998/10/10 J Bacteriol. 1998 Oct; 180(20):5443-7. doi: 10.1128/JB.180.20.5443-5447.1998"