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Chem Res Toxicol

Title:		In Situ Derivatization and Quantification of Seven Carbonyls in Cigarette Mainstream Smoke
Author(s):		Ding YS; Yan X; Wong J; Chan M; Watson CH;
Address:		"Tobacco Product Laboratory, Centers for Disease Control and Prevention , Atlanta, Georgia 30341, United States"
Journal Title:		Chem Res Toxicol
Year:		2016
Volume:		20160106
Issue:		1
Page Number:		125 - 131
DOI:		10.1021/acs.chemrestox.5b00474
ISSN/ISBN:		1520-5010 (Electronic) 0893-228X (Print) 0893-228X (Linking)
Abstract:		"Carbonyls, especially aldehydes, are a group of harmful volatile organic compounds that are found in tobacco smoke. Seven carbonyls are listed on the FDA's harmful and potential harmful constituents list for tobacco or tobacco smoke. Carbonyls have reactive functional groups and thus are challenging to quantitatively measure in cigarette smoke. The traditional method of measuring carbonyls in smoke involves solvent-filled impinger trapping and derivatization. This procedure is labor-intensive and generates significant volumes of hazardous waste. We have developed a new method to efficiently derivatize and trap carbonyls from mainstream smoke in situ on Cambridge filter pads. The derivatized carbonyls are extracted from the pads and subsequently quantified by ultra-high-pressure liquid chromatography coupled with tandem mass spectrometry. The new method has been validated and applied to research and commercial cigarettes. Carbonyl yields from research cigarettes are comparable to those from other published literature data. With a convenient smoke collection apparatus, a 4 min sample analysis time, and a low- or submicrogram detection limit, this new method not only simplifies and speeds the detection of an important class of chemical constituents in mainstream smoke but also reduces reactive losses and provides a more accurate assessment of carbonyl levels in smoke. Excellent accuracy (average 98%) and precision (14% average relative standard deviation in research cigarettes) ensure this new method's sufficient fidelity to characterize conventional combusted tobacco products, with potential application toward new or emerging products"
Keywords:		"Aldehydes/*analysis/*chemistry Chromatography, High Pressure Liquid Smoke/*analysis Tandem Mass Spectrometry Tobacco/*chemistry *Tobacco Products;"
Notes:		"MedlineDing, Yan S Yan, Xizheng Wong, Joshua Chan, Michele Watson, Clifford H eng CC999999/Intramural CDC HHS/ Research Support, U.S. Gov't, P.H.S. 2015/12/25 Chem Res Toxicol. 2016 Jan 19; 29(1):125-31. doi: 10.1021/acs.chemrestox.5b00474. Epub 2016 Jan 6"